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Induction of an intestinal epithelial sugar transport system by high blood sugar

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Summary

Intravenous infusion of glucose produces a marked increase of the mucosal-to-serosal sugar flux in the isolated everted small intestine of rats. The phenomenon is partially substrate specific, is inhibited by phloretin but not by phlorizin and is completely abolished by cycloheximide. The results suggest that sustained hyperglycemia may stimulate the synthesis of new transport receptors (carriers).

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Author notes

  1. E. Fischer

    Present address: Department of Pharmacology, Medical University of Pécs, 7643, Pécs, Hungary

Authors and Affiliations

  1. Department of Pharmacology, University of Kentucky, College of Medicine, 40506, Lexington, Kentucky, USA

    T. Z. Csáky & E. Fischer

Authors
  1. T. Z. Csáky
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  2. E. Fischer
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Additional information

Acknowledgment. This work was supported by U. S. P. H. research, grant No. 5 Rol AM15734-14.

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Csáky, T.Z., Fischer, E. Induction of an intestinal epithelial sugar transport system by high blood sugar. Experientia 33, 223–224 (1977). https://doi.org/10.1007/BF02124079

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