Summary
Surgical specimens of human gastrointestinal mucosa and muscle were incubated in vitro with thiaminethiazole-2-14C. Labelled thiamine uptake was uphill in mucosal tissues and downhill in muscle. Small intestinal mucosa accumulated labelled thiamine in a phosphorylated form, while gastric and colonic mucosa, as well as muscular layers of all gastrointestinal segments studied, did not.
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References
A. C. Da Silva and A. C. Ivy, Am. J. Physiol.201, 185 (1961).
A. C. Da Silva, M. G. Vecchia, R. N. Rogano and R. C. De Angelis, 23rd, Int. Cong. Physiol. Sci. Tokyo 1965, p. 220.
U. Ventura, E. Giacalone and G. Rindi, Boll. Soc. ital. Biol. sper.39, 1443 (1963).
B. Gassmann, J. Proll and D. Lexow, Int. Z. Vitaminforsch.37, 203 (1967).
E. Sandner and B. Gassmann, Nahrung11, 583 (1967).
G. Sciorelli and U. Ventura, Acta vitamin enzym.23, 231 (1969).
D. Polin, E. R. Wynosky and C. C. Porter, Fed. Proc.21, 261 (1962).
D. Polin, E. R. Wynosky and C. C. Porter, Poult. Sci.42, 1057 (1963).
K. R. Fox and C. A. M. Hogben, Fed. Proc.26, 502 (1967).
U. Ventura and G. Rindi, Experientia21, 645 (1965).
T. Komai, K. Kawai and H. Shindo, J. Nutr. Sci. Vitamin.20, 163 (1974).
T. Komai and H. Shindo, J. Nutr. Sci. Vitamin.20, 179 (1974).
A. M. Hoyumpa, H. M. Middleton, F. A. Wilson and S. Schenker, Gastroenterology68, 1218 (1975).
K. Schaller and H. Höller, Int. J. Vit. Nutr. Res.44 443 (1974).
G. Rindi and U. Ventura, Physiol. Rev.52, 821 (1972).
A. S. Schultz, R. F. Light and C. N. Frey, Proc. Soc. exp. Biol. Med.38, 404 (1938).
B. Alexander, G. Landwehr and F. Mitchell, J. clin. Invest.25, 294 (1946).
T. E. Friedemann, T. C. Kmieciak, P. K. Keegan and B. B. Sheft, Gastroenterology11, 100 (1948).
A. B. Morrison and J. A. Campbell, J. Nutr.72, 435 (1960).
A. D. Thomson, H. Baker and C. M. Leevy, J. Lab. Clin. Med.76, 34 (1970).
A. D. Thomson and C. M. Leevy, Clin. Sci.43, 153 (1972).
G. Levy and R. R. Hewitt, Am. J. Clin. Nutr.24, 401 (1971).
H. A. Krebs and K. Henseleit, Hoppe-Seylers Z. physiol. Chem.210, 33 (1932).
R. K. Crane and P. Mandelstam, Biochim. biophys. Acta, Amst.45, 460 (1960).
G. Rindi and U. Ventura, Experientia23, 175 (1967).
S. K. Sharma and J. H. Quastel, Biochem. J.94, 790 (1965).
H. B. Burch, O. A. Bessey, R. H. Love and O. H. Lowry, J. biol. Chem.198, 477 (1952).
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This work was supported in part by a grant from the Italian Research Council, Rome, Italy.
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Rindi, G., Ferrari, G. Thiamine transport by human intestine in vitro. Experientia 33, 211–213 (1977). https://doi.org/10.1007/BF02124072
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DOI: https://doi.org/10.1007/BF02124072