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Clinical and serologic effects of Alice strain live attenuated influenza A (H3N2) virus vaccine in an adult population

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Abstract

Alice strain live attenuated influenza A (H3N2) virus vaccine was evaluated in prison volunteers. By random double blind allocation, 94 volunteers received Alice strain vaccine (AS) intranasally and 97 received placebo. The vaccine was well tolerated, and there was no serious morbidity. The number, type, duration, and severity of symptoms was not significantly different between the vaccine and placebo groups.

Seventy-five per cent of vaccinees with initial HAI titers less than or equal to 1∶8 had 4 fold or greater titer responses on day 30. Placebo recipients experienced no titer changes. The GMT among vaccinees increased from 23.5 prior to vaccination 59.7 30 days later. Surveillance activities failed to document influenza A (H3N2) infection in the volunteer population during a 6 month follow-up period. Additional studies on the protective effects of the vaccine are required before efficacy can be determined.

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Authors and Affiliations

  1. Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, Baltimore, Md.

    Louis W. Miller, Yasushi Togo & Richard B. Hornick

Authors
  1. Louis W. Miller
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  2. Yasushi Togo
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  3. Richard B. Hornick
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Additional information

This study was aided by a Public Health Service training grant, PHS AH00037-05, and a research contract with Smith, Kline and French Laboratories, Philadelphia, Pennsylvania.

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Miller, L.W., Togo, Y. & Hornick, R.B. Clinical and serologic effects of Alice strain live attenuated influenza A (H3N2) virus vaccine in an adult population. Med Microbiol Immunol 162, 15–21 (1975). https://doi.org/10.1007/BF02123573

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  • DOI: https://doi.org/10.1007/BF02123573

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