Medical Microbiology and Immunology

, Volume 174, Issue 2, pp 73–80 | Cite as

Neutralising antibody against type 1 and type 2 herpes simplex virus in cervical mucus of women with cervical intra-epithelial neoplasia

  • J. F. Murphy
  • D. F. Murphy
  • S. Barker
  • M. L. Mylotte
  • B. M. Coughlan
  • G. R. B. Skinner


Patients with cervical intra-epithelial neuoplasia had significantly increased neutralising antibody activity to type 2 herpes simplex virus in the cervical mucus. While patients differed from control subjects with respect to their number of sexual partners and socio-economic class, there were significant differences in neutralising antibody activity for case control comparisons within the same number of sexual partners or socio-economic groupings. The results lend support to the putative association between type 2 herpes simplex virus infection and pre-invasive and invasive carcinoma of the uterine cervix.


Carcinoma Virus Infection Control Subject Sexual Partner Herpes Simplex 
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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • J. F. Murphy
    • 1
  • D. F. Murphy
    • 1
  • S. Barker
    • 2
  • M. L. Mylotte
    • 2
  • B. M. Coughlan
    • 2
  • G. R. B. Skinner
    • 2
  1. 1.Coombe Lying-in HospitalDublin 8UK
  2. 2.Department of Medical MicrobiologyUniversity of BirminghamBirminghamUK

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