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Medical Microbiology and Immunology

, Volume 174, Issue 2, pp 73–80 | Cite as

Neutralising antibody against type 1 and type 2 herpes simplex virus in cervical mucus of women with cervical intra-epithelial neoplasia

  • J. F. Murphy
  • D. F. Murphy
  • S. Barker
  • M. L. Mylotte
  • B. M. Coughlan
  • G. R. B. Skinner
Article
  • 14 Downloads

Abstract

Patients with cervical intra-epithelial neuoplasia had significantly increased neutralising antibody activity to type 2 herpes simplex virus in the cervical mucus. While patients differed from control subjects with respect to their number of sexual partners and socio-economic class, there were significant differences in neutralising antibody activity for case control comparisons within the same number of sexual partners or socio-economic groupings. The results lend support to the putative association between type 2 herpes simplex virus infection and pre-invasive and invasive carcinoma of the uterine cervix.

Keywords

Carcinoma Virus Infection Control Subject Sexual Partner Herpes Simplex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Ackers JP, Lumsden WHR, Catherall RD, Coyle R (1975) Antitrichomonal Antibody in the Vaginal Secretions of women infected with T. vaginals. British Journal of Venereal Disease 51: 319Google Scholar
  2. Adam E, Kaufman RH, Melnick RH, Levy AH, Rawls WE (1974) Seroepidemiologic Studies of herpes virus Type 2 and carcinoma of the cervix. IV. Dysplasia and carcinoma in situ. American Journal of Epidemiology 98: 77Google Scholar
  3. Adelusi B, Naib Z, Muther J, Nahmias AJ (1980) Epidemiological studies relating genital herpes simplex virus (HSV) infection with cervical neoplasia — an update. Proceedings of the International Conference on Human Herpes Viruses, Atlanta, GeorgiaGoogle Scholar
  4. Behrmann SJ, Lieberman ME (1973) Biosynthesis of Immunooglobulins by the Human Cervix. In: Blandau RJ, Moghissi K (eds) Biology of the Cervix, University of Chicago Press, Chicago, p. 235Google Scholar
  5. Berger R, Ainbender E, Hodes HL (1967) Demonstration of lgA Polioantibody in saliva, duodenal fluid & urine. Nature 214:420PubMedGoogle Scholar
  6. Coughlan BM, Skinner GRB (1977a) Immunoglobulin concentrations in cervical mucus in patients with normal and abnormal cervical cytology. British Journal of Obstetrics and Gynaecology 84: 129PubMedGoogle Scholar
  7. Coughlan BM, Skinner GRB (1977b) Antibody activity to type 1 and type 2 herpes simples virus in human cervical mucus. British Journal of Obstetrics and Gynaecology 84:622PubMedGoogle Scholar
  8. Cowan ME, Buchan A, Skinner GRB (1982) Synthesis of Immunoglobulins by human endocervix in organ culture. British Journal of Experimental Pathology 63: 125PubMedGoogle Scholar
  9. Eglin RP, Maclean AB, Sharp F, Macnab JCM, Clements JB, Wilkie NM (1981) The detection of herpes virus coded material in neoplastic cervical tissue. In: Nahmias AJ, Dowdle WR and Schinazi RF (eds) The human herpes viruses, New York, Elsevier p. 630Google Scholar
  10. Francis T (1940) Inactivation of Epidemic Influenza virus by nasal secretions of human individuals. Journal of Bacteriology 39: 54Google Scholar
  11. Govan ADT, Haines RM, Langley FA, Taylor CN, Woodcock AS (1966) Changes in the epithelium of the cervix uteri. Journal of Obstetrics and Gynaecology of the British Commonwealth 73: 883PubMedGoogle Scholar
  12. Govan ADT, Haines RM, Langley FA, Taylor CW, Woodcock AS (1969) The histology and cytology of changes in the epithelium of the cervix uteri. Journal of Clinical Pathology 22: 383PubMedGoogle Scholar
  13. Harris RWC (1980) Characteristics of women with dysplasia or carcinoma in situ of the cervix uteri. British Journal of Cancer 42: 359PubMedGoogle Scholar
  14. Macmillan A, McNeillage G, Young H, Bain SSR (1979) Secretary antibody response of the cervix to infection with neisseria gonorrhoeae. British Journal of Venereal Disease 55: 265Google Scholar
  15. Macpherson I, Stoker M (1962) Polyoma transformation of hamster cell clones and an investigation of genetic factors affecting cell competence. Virology 16: 147CrossRefPubMedGoogle Scholar
  16. Naib ZM, Nahmias AJ, Josey WE (1966) Cytology and histopathology of cervical herpes simplex infection. Cancer 19: 1026PubMedGoogle Scholar
  17. Ogra PL, Ogra SS (1973) Local antibody response to poliovaccine in the human female genital tract. Journal of Immunology 110: 1307Google Scholar
  18. Parrish WE, Ward A (1968) Studies of cervical mucus and serum from infertile women. Journal of Obstetrics and Gynaecology of the Brtitsh Commonwealth 75: 1089Google Scholar
  19. Plummer G, Goodheart CR, Miyagi M, Skinner GRB, Thouless ME, Wildy P (1974) Herpes simplex viruses. Discrimination of types and correlation between different characteristics. Virology 60: 206CrossRefPubMedGoogle Scholar
  20. Richart RM, Yao-Shi Fu, Regan JW (1981) Pathology of cervical intra-epithelial neoplasia. In: Coppleson M, Churchill-Livingstone (eds) Gynaecologic Oncology. London, p. 398Google Scholar
  21. Russel WC (1962) A sensitive and precise plaque assay for herpes virus. Nature 195:1028PubMedGoogle Scholar
  22. Skinner GRB, Thouless ME, Jordan JA (1971) Antibodies to type 1 and type 2 herpes virus in women with abnormal cervical cytology. The Journal of Obstetrics and Gynaecology of the British Commonwealth 78: 1031PubMedGoogle Scholar
  23. Skinner GRB (1976) Transformation of primary hamster embryo fibroblasts by type 2 simplex virus evidence for a “hit and run” mechanism. British Journal of Experimental Pathology 57:361PubMedGoogle Scholar
  24. Skinner GRB, Thouless ME, Tureman S, Edwards J, Gibbs AJ (1976) Seriological relatedness of herpes simplex viruses type specificity of antibody response. Immunology 31: 481PubMedGoogle Scholar
  25. Skinner GRB, Whitney JE, Hartley C (1977) Prevalence of type-specific antibody against type 1 and type 2 herpes simplex virus in women with abnormal cervical cytology; evidence towards pre-pubertal vaccination of sero-negative female subjects. Archives of Virology 54: 211CrossRefPubMedGoogle Scholar
  26. Skinner GRB, Woodman C, Hartley CE, Buchan A, Fuller A (1982) The prevention of herpes simplex virus induced cervical carcinoma. Proceedings 9th College Study Group on preclinical neoplasia of the cervix, 4th World Congress for cervical pathology and colposcopy. Published by the Royal College Obstetricians and GynaecologistsGoogle Scholar
  27. Vantsis FJ, Wildy P (1962) Interaction of herpes virus and HeLa cells, comparison of cell killing and infective center formation. Virology 17: 225CrossRefPubMedGoogle Scholar
  28. Waldman RH, Wood SH, Torres EJ, Small PA (1970) Influenza antibody response following aerosol administration of inactivated virus. American Journal of Epidemiology 91: 574PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • J. F. Murphy
    • 1
  • D. F. Murphy
    • 1
  • S. Barker
    • 2
  • M. L. Mylotte
    • 2
  • B. M. Coughlan
    • 2
  • G. R. B. Skinner
    • 2
  1. 1.Coombe Lying-in HospitalDublin 8UK
  2. 2.Department of Medical MicrobiologyUniversity of BirminghamBirminghamUK

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