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Neutralising antibody against type 1 and type 2 herpes simplex virus in cervical mucus of women with cervical intra-epithelial neoplasia

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Abstract

Patients with cervical intra-epithelial neuoplasia had significantly increased neutralising antibody activity to type 2 herpes simplex virus in the cervical mucus. While patients differed from control subjects with respect to their number of sexual partners and socio-economic class, there were significant differences in neutralising antibody activity for case control comparisons within the same number of sexual partners or socio-economic groupings. The results lend support to the putative association between type 2 herpes simplex virus infection and pre-invasive and invasive carcinoma of the uterine cervix.

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Author notes

  1. J. F. Murphy (Consultant Obstetrician/Gynaecologist)

    Present address: National Maternity Hospital, Dublin 2, UK

Authors and Affiliations

  1. Coombe Lying-in Hospital, Dublin 8, UK

    J. F. Murphy (Consultant Obstetrician/Gynaecologist) & D. F. Murphy

  2. Department of Medical Microbiology, University of Birmingham, B15 2TZ, Birmingham, UK

    S. Barker, M. L. Mylotte, B. M. Coughlan & G. R. B. Skinner

Authors
  1. J. F. Murphy
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  2. D. F. Murphy
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  3. S. Barker
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  4. M. L. Mylotte
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  5. B. M. Coughlan
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  6. G. R. B. Skinner
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Murphy, J.F., Murphy, D.F., Barker, S. et al. Neutralising antibody against type 1 and type 2 herpes simplex virus in cervical mucus of women with cervical intra-epithelial neoplasia. Med Microbiol Immunol 174, 73–80 (1985). https://doi.org/10.1007/BF02123228

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  • DOI: https://doi.org/10.1007/BF02123228

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