Summary
Patients with abnormal cervical cytology demonstrated a higher prevalence of type-specific complement-fixing antibody to type 2 herpes simplex virus than patients with negative cervical cytology and patients with carcinoma of other body sites. Case-control differences were apparent irrespective of age, socioeconomic class and marital status. By contrast, case groups demonstrated a lower prevalence of subjects with type 1 specific antibody. This raises the possibility that pre-adolescent exposure to type 1 herpes simplex virus may offer some measure of protection against pre-malignant and malignant cervical pathology.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Rawls, W. E., Tompkins, W. A. F., Figueroa, M., Melnick, J. L.: Herpes virus type 2: association of the cervix. Science161, 1255 (1968).
Skinner, G. R. B., Thouless, M. E., Jordan, J. A.: Antibodies to type 1 and type 2 herpes virus in women with abnormal cervical cytology. J. Obst. Gynaecol. Brit. Commonwealth78, 1031 (1971).
Sprecher-Goldberger, S., Thiry, L., Gould, I., Fassin, Y., Gampel, C.: Increasing antibody titres to herpes simplex virus type 2 during follow-up of women with cervical dysplasia. Amer. J. Epidemiol.97, 103 (1972).
Adam, E., Kaufman, R. H., Melnick, J. L., Levy, A. H., Rawls, W. E.: Seroepidemiologic studies of herpes virus type 2 and carcinoma of the cervix IV. Amer. J. Epidemiol.98, 77 (1974).
Rawls, W. E., Tompkins, W. A. F., Melnick, J. L.: The association of herpes type 2 and carcinoma of the uterine cervix. Amer. J. Epidemiol.80, 547 (1969).
Nahmias, A. J., Josey, W. E., Naib, Z. M., Luce, C. F., Duffey, A.: Antibodies to herpesvirus hominis types 1 and 2 in humans. 1. Patients with genital herpetic infection. 2. Women with cervical cancer. Amer. J. Epidemiol.91, 539 (1970).
Plummer, G., Masterson, J. G.: Herpes simplex virus and cancer of the cervix. Amer. J. Obst. Gynaecol.111, 81 (1971).
Vestergaard, B. F., Hornsleth, A., Pedersen, S. N.: Occurrence of herpes and adenovirus antibodies in patients with carcinoma of the cervix uteri. Cancer30, 68 (1972).
Kawana, T., Yoshino, K., Kassamatsu, T.: Estimation of specific antibody type 2 herpes simplex virus among patients with carcinoma of the uterine cervix. Gann65, 439 (1974).
Wildy, P.: Herpesvirus and antigens: In:Biggs, P. M., de Thé, G., Payne, G. L. (eds.), Oncogenesis and Herpesviruses, 409. Lyon: International Agency for Research on Cancer 1972.
Skinner, G. R. B., Taylor, J., Edwards, J.: Precipitating antibodies to herpes simplex virus in human sera: prevalence of antibody to common antigen (Band II). Intervirology4, 320 (1974).
Skinner, G. R. B., Thouless, M. E., Trueman, S., Edwards, J.: Serological relatedness of herpes simplex viruses; type specificity of immune response. Brit. J. Immunol.31, 481.
Skinner, G. R. B., Hartley, C., Whitney, J. E.: Detection of type-specific antibody to herpes simplex virus type 1 and 2 in human sera by complement-fixation tests. Arch. Virol.50, 323 (1976).
Papanicalaou, G., Trout, H. F.: The diagnoses of uterine cancer by the vaginal smear. New York: The Commonwealth Fund 1943.
Govan, A. D. T., Harris, R. M., Langley, F. A., Taylor, C. W., Woodcock, A. S.: Changes in the epithelium of the cervix uteri. J. Obst. Gynaecol. Brit. Commonwealth73, 883 (1966).
Wildy, P.: Recombination with herpes simplex virus. J. gen. Microbiol.13, 340 (1955).
Geder, L., Skinner, G. R. B.: Differentiation between type 1 and type 2 strains of herpes simplex virus by an indirect immunofluorescent technique. J. gen. Virol.12, 179 (1971).
Plummer, G., Goodheart, C. R., Miyagi, M., Skinner, G. R. B., Thouless, M. E., Wildy, P.: Herpes simplex viruses: Discrimination of types and correlation between different characteristics. Virology60, 206 (1974).
MacPherson, I., Stoker, M.: Polyoma transformation of hamster cell clones—an investigation of genetic factors affecting cell competence. Virology16, 147 (1962).
Watson, D. H., Shedden, W. I. H., Elliot, A., Tetsuka, T., Wildy, P., Bourgaux-Ramoisy, D., Gold, E.: Virus specific antigens in mammalian cells infected with herpes simplex virus. Immunology11, 399 (1966).
Royston, I., Aurelian, L.: The association of genital herpesvirus with cervical atypia and carcinomain situ. Amer. J. Epidemiol.91, 531 (1970).
Catalano, W. L., Johnson, L. D.: Herpesvirus antibody and carcinomain situ of the cervix. J. Amer. med. Assoc.217, 447 (1971).
Stevens, J. G., Cook, M. L.: Latent herpes simplex virus in spinal ganglia of mice. Science173, 843 (1971).
Skinner, G. R. B.: Transformation of mammalian cells by type 2 herpes simplex virus; evidence for a ‘hit-and-run’ mechanism. Brit. J. exp. Pathol.57, 361 (1976).
Author information
Authors and Affiliations
Additional information
With 1 Figure
Rights and permissions
About this article
Cite this article
Skinner, G.R.B., Whitney, J.E. & Hartley, C. Prevalence of type-specific antibody against type 1 and type 2 herpes simplex virus in women with abnormal cervical cytology; evidence towards pre-pubertal vaccination of sero-negative female subjects. Archives of Virology 54, 211–221 (1977). https://doi.org/10.1007/BF01314787
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01314787