Abstract
In attempting to explain the mechanism whereby hemoglobin is released during NDV-induced hemolysis it was found that marker substances like albumin or myoglobin with diameters larger than 30 Å are retained in the erythrocyte membrane, whereas low molecular weight material is released. This indicates that NDV-induced hemolysis does not result in the formation of membrane lesions but rather in the alteration of membrane permeability. A prerequisite for this process is the insertion of viral envelope components into the cell membrane.
NDV-induced hemolysis can be enhanced by virus-specific antibodies and complement. In this case the release of marker substances is due to membrane lesions since large molecules also are released from the erythrocytes.
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The work was supported by the Sonderforschungsbereich 47
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Sziegoleit, A., Füssle, R. & Rott, R. Alteration of the erythrocyte membrane during newcastle disease virus-induced hemolysis. Med Microbiol Immunol 165, 101–109 (1978). https://doi.org/10.1007/BF02122745
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DOI: https://doi.org/10.1007/BF02122745