Abstract
Chinoform, iodochlorhydroxyquin, was found to suppress the antiviral action of interferon. Chick embryo fibroblast cells treated with the mixture of interferon and chinoform were more sensitive to Sindbis virus infection than cells treated with interferon alone. No evidence for a direct inactivation of interferon molecule by chinoform was obtained. Treatment with chinoform of cells previously exposed to interferon also removed a cellular antiviral state induced by interferon. Chinoform suppressed intracellular ribonucleic acid (RNA) and protein syntheses. It is suggested that the inhibitory effect of chinoform on the action of interferon is due to a suppression of continued production of antiviral proteins.
Similar content being viewed by others
References
Baron, S., Buckler, C.E., Levy, H.B., Friedman, R.M.: Some factors affecting the interferon-induced antiviral state. Proc. Soc. exp. Biol. (N.Y.)125, 1320–1326 (1967)
Chany, C., Brailovsky, C.: Stimulating interaction between viruses (stimulons). Proc. nat. Acad. Sci. (Wash.)57, 87–94 (1967)
Fournier, F., Rousset, S., Chany, C.: Investigations on a tissue antagonist of interferon (TAI). Proc. Soc. exp. Biol. (N.Y.)132, 947–950 (1969)
Friedman, R.M., Sonnabend, J.A.: Inhibition of interferon action by p-fluoro-phenylalanine. Nature (Lond.)203, 366–367 (1964)
Ghendon, Yu.Z., Balandin, I.G., Babushkina, L.M.: On the mechanism of the ability of certain viruses to block the action of interferon. Acta Virol.10, 268–170 (1966)
Levine, S.: Effect of antinomycin D and puromycin dihydrochloride on action of interferon. Virology24, 586–588 (1964)
Levy, H.B., Merigan, T.C.: Interferon and uninfected cells. Proc. Soc. exp. Biol. (N.Y.)121, 53–55 (1966)
Lockart, R.Z. Jr.: The necessity for cellular RNA and protein synthesis for viral inhibition resulting from interferon. Biochem. biophys. Res. Commun.15, 513–518 (1964)
Mécs, I.: The effect of purine and pyrimidine compounds on the virus-host cell interaction. 2. The effect on interferon action. Acta Virol.12, 491–496 (1968)
Nagata, I., Kimura, Y., Matsumoto, T., Maeno, K., Yoshii, S., Nagai, Y., Iinuma, M.: Plaque variants of Sindbis virus. Arch. ges. Virusforsch.22., 79–86 (1967)
Rossman, T.G., Vilcek, J.: Blocking of interferon action by a component of normal serum. Arch. ges. Virusforsch.31, 18–27 (1970)
Taylor, J.: Inhibition of interferon action by actinomycin. Biochem. biophys. Res. Commun.14, 447–451 (1964)
Truden, J.L., Sigel, M.M., Dietrich, L.S.: An interferon antagonist: its effect on interferon action in mengo-infected Ehrlich ascites tumor cells. Virology33, 95–103 (1967)
Yamanaka, N., Imanari, T., Tamura, Z., Yagi, K.: Uncoupling of oxidative phosphorylation of rat liver mitochondria by chinoform. J. Biochem.73, 993–998 (1973)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kimura, Y. Inhibition of interferon action by chinoform. Med Microbiol Immunol 167, 189–195 (1979). https://doi.org/10.1007/BF02121185
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02121185