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C-type virus particles in phytohemagglutinin-stimulated lymphocyte cultures with reference to enzootic lymphatic leukosis in sheep

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Summary

C-type virus particles were demonstrated by electron microscopy in phytohemagglutinin-stimulated lymphocyte cultures from sheep. Virus particles were observed in cultures from 7 animals with confirmed diagnosis of lymphatic leukosis or with persistent lymphocytosis, and not at all in cultures from 38 sheep of the same herd without signs of leukosis. It was concluded that the observation of virus particles in lymphocyte cultures may be associated with leukosis in sheep.

Zusammenfassung

In Phytohämagglutinin-stimulierten Lymphocytenkulturen von Schafen konnten elektronenmikroskopisch C-Typ-Viruspartikel nachgewiesen werden. Die Viruspartikel wurden bei insgesamt 7 Tieren gefunden, die an lymphatischer Leukose erkrankt waren oder eine persistierende Lymphocytose zeigten. Untersuchungen an Kulturen von 38 weiteren Tieren derselben Herde, bei denen keine Anzeichen von Leukose feststellbar waren, verliefen negativ. — Es wird auf einen möglichen Zusammenhang zwischen dem Auftreten von C-Typ-Virus und der lymphatischen Leukose bei Schafen geschlossen.

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Authors and Affiliations

  1. Institut für Hygiene und Infektionskrankheiten der Tiere, Germany

    J. Paulsen, R. Rudolph, R. Hoffmann, E. Weiss & Th. Schliesser

  2. Institut für Veterinär-Pathologie, Justus Liebig-Universität, Giessen, Germany

    J. Paulsen, R. Rudolph, R. Hoffmann, E. Weiss & Th. Schliesser

Authors
  1. J. Paulsen
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  2. R. Rudolph
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  3. R. Hoffmann
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  4. E. Weiss
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  5. Th. Schliesser
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Paulsen, J., Rudolph, R., Hoffmann, R. et al. C-type virus particles in phytohemagglutinin-stimulated lymphocyte cultures with reference to enzootic lymphatic leukosis in sheep. Med Microbiol Immunol 158, 105–112 (1972). https://doi.org/10.1007/BF02120475

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  • DOI: https://doi.org/10.1007/BF02120475

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