Abstract
The distributions of vasoactive intestinal polypeptide, peptide histidine methionine, helospectin, neuropeptide Y and its C-flanking peptide, substance P and calcitonin gene-related peptide were studied in the human soft palate using immunocytochemical techniques. Peptide-containing nerve fibers were found to form a dense network around glandular acini, excretory ducts and blood vessels, as well as beneath and within the epithelium. Chromogranin A, bombesin-flanking peptide and calcitonin gene-related peptide immunoreactivities were detected in endocrine-like cells located in excretory ducts.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Albegger K, Oberascher G (1992) Unerwünschte Arzneimittelwirkungen in den oberen Luft- and Speisewegen. Otorhinolaryngol Nova 2:169–177
Albegger K, Hauser-Kronberger C, Saria A, Graf A-H, Bernatzky G, Hacker GW (1991) Regulatory peptides and general neuroendocrine markers in the human nasal mucosa, the soft palate and the larynx. Acta Otolaryngol (Stockh) 111:373–378
Alving K, Sundström C, Matran R, Panula P, Hökfelt T, Lundberg JM (1991) Association between histamine-containing mast cells and sensory nerves in the skin and airways of control and capsaicin-treated pigs. Cell Tissue Res 264:529–538
araniuk JN, Kaliner MA (1990) Neuropeptides and nasal secretion. J Allergy Clin Immunol 86:620–627
Basterra J, Dilly PN, PerezM, Chumbley CC (1989) Vasoactive intestinal polypeptide and neuropeptide-Y, as possible mediators in laryngeal oedema. An immunofluorescence study. Acta Otorhinolaryngol (Belg) 43:99–104
Bumsted RM (1988) Velopharyngeal incompetence. In: English GM (ed) Otolaryngology, vol 4. Plastic and reconstructive surgery of the head and neck. Lippincott, Philadelphia, pp 25–48
Cadieux A, Springall DR, Mulderry PK (1986) Occurrence, distribution and ontogeny of CGRP immunoreactivity in the rat lower respiratory tract: effect of capsaicin treatment and surgical denervations. Neuroscience 19:605–627
Coons AH, Leduc EH, Connolly JM (1955) Studies on antibody production. I. A method for the histochemical demonstration of specific antibody and its application to a study of the hyperimmune rabbit. J Exp Med 102:49–60
Grains FW (1954) The sensory nerve endings in the human palate. J Physiol (Loud) 123:26–27
Hacker GW, Grimelius L, Danscher G (1988) Silver acetate autometallography - an alternative enhancement technique for immunogold-silver staining (IGSS) and silver amplification of gold, silver, mercury and zinc tissues. J Histotechnol 11: 213–221
Hauser-Kronberger C, Hacker GW, Sundler F, Albegger K (1992) Distribution and colocalization of immunoreactive helospectin with vasoactive intestinal polypeptide and peptide histidine methionine in human nasal mucosa, soft palate and larynx. Eur Arch Otorhinolaryngol 249:201–205
Hollinshead WH (1989) Anatomy of the pharynx and oesophagus. In: English GM (ed) Otolaryngology, vol 3. Diseases of the larynx, pharynx and upper respiratory tract. Lippincott, Philadelphia, pp 1–53
Lundberg JM, Martling C-R, Saria A, Folkers S, Rosell S (1983) Cigarette smoke induced edema due to activation of capsaicin-sensitive vagal afferents and substance P release. Neurosci Lett 10:1361–1368
awa H, Hayama T, Itho S (1982) Convergence of input from tongue and palate to the parabranchial nucleus neurons of rats. Neursci Lett 2:9–14
Rodrigo J, Polak JM, Terenghi G (1985) Calcitonin gene-related peptide (CGRP)-immunoreactive sensory and motor nerves of the mammalian palate. Histochemistry 82:67–74
Weihe E, Müller S, Fink T, Zentel HJ (1989) Tachykinins calcitonin gene-related peptide and neuropeptide Y in nerves of the mammalian thymus: interactions with mast cells in autonomic and sensory neuroimmunomodulation? Neurosci Lett 100:77–82
amboni L, De Martino C (1967) Buffered picric acid formaldehyde: a new rapid fixative for electron microscopy (abstract). J Cell Biol 35:148A
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hauser-Kronberger, C., Hacker, G.W., Kummer, W. et al. Regulatory peptides in the human soft palate. Eur Arch Otorhinolaryngol 252, 478–484 (1995). https://doi.org/10.1007/BF02114755
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02114755