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Effect of histidine on morphine-induced changes in brain histamine

  • Histamine and Kinins
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Abstract

Chronic morphine administration to rats resulted in a significant decrease in the hypothalamic and cerebro-cortical histamine concentrations. These low histamine values were restored to control levels whenl-histidine was administered daily along with morphine treatment. Chronic treatment withl-histidine prevented the midbrain and cerebro-cortical histamine depletion in morphine-withdrawn rats, whereas in the hypothalamus the histamine level remained significantly decreased.

The present data suggests that histamine may play a role in morphine dependence and withdrawal.

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References

  1. E. Costa, A. Carenzi, A. Guidotti andA. Revuelta,Narcotic Analgesics and the Regulation of Neuronal Catecholamine Stores, in:Frontiers in Catecholamine Research (Eds. E. Usdin and S. Snyder; 1973), pp. 1003–1010.

  2. E.L. Way andF.H. Shen,The Effects of Narcotic Analgesics on Specific Systems, in:Narcotic Drugs, Biochemical Pharmacology (Ed. D.H. Clouet; Plenum Press, New York, 1971), pp. 229–253.

    Google Scholar 

  3. C.B. Smith,Neurotransmitters and the Narcotic Analgesics, in:Chemical and Biological Aspects of Drug Dependence (Eds. S.Y. Mule and H. Brill; C.R.S. Press, Cleveland, Ohio, 1974), pp. 495–504.

    Google Scholar 

  4. D.H. Clouet andK. Iwatsubo,Methods of Producting Tolerance and Dependence in Laboratory Animals, in:Mechanisms of Tolerance to and Dependence on Narcotic Analgesis Drugs, Ann. Rev. Pharmacol.15, 49–71 (1975).

  5. K. Dismukes andS.H. Snyder,Dynamics of Brain Histamine, Adv. Neurol5, 101–109 (1974).

    PubMed  Google Scholar 

  6. J.C. Schwartz,Histamine as a Transmitter in the Brain, Life Sci.17, 503–518 (1976).

    Google Scholar 

  7. J.C. Schwartz, M. Baudry, S. Bischoff, M.P. Martes, H. Pollard, C. Rose andM. Verdiere,Pharmacological Studies of Histamine as a Central Neurotransmitter, in:Drugs and Central Synaptic Transmission (eds. P.D. Bradley and B.N. Dhawan; University Park Press, Baltimore, 1976), pp. 371–382.

    Google Scholar 

  8. R.W. Henwood andI.M. Mazurkiewicz-Kwilecki,Possible Role of Brain Histamine in Morphine Addiction, Life Sci.17, 55–56 (1975).

    PubMed  Google Scholar 

  9. I.M. Mazurkiewicz-Kwilecki andR.W. Henwood,Alterations in Brain Endogenous Histamine Levels in Rats After Chronic Morphine Treatment and Morphine Withdrawal, Agents and Actions6 (4), 402–408 (1976).

    PubMed  Google Scholar 

  10. I.M. Mazurkiewicz-Kwilecki andB. Bielkiewicz The Effect of Chronic Morphine Treatment on Histamine Concentration and Histidine Decarboxylase Activity in Rat Brain, Progress in Neuropsychopharmacol. (1977) (in press).

  11. J.C. Schwartz, C. Lampart and C. RoseHistamine Formation in Rat Brain in vivo: Effects of Histidine Loads, J. Neurochem.19, 801–810 (1972).

    PubMed  Google Scholar 

  12. K.M. Taylor andS.H. Snyder,Dynamics of the Regulation of Histamine Levels in Mouse Brain. J. Neurochem.19, 341–354 (1972).

    PubMed  Google Scholar 

  13. A.E. Takemori Enzyme Studies on Morphine Glucuronide Synthesis in Acutely and Chronically Morphinized Rats, J. Pharmacol. Exptl. Therap.130, 370–374 (1960).

    Google Scholar 

  14. J. Glowinski andL.L. Iversen,Regional Studies on Catecholamines in the Rat Brain, J. Neurochem.13, 655 (1966).

    PubMed  Google Scholar 

  15. K.M. Taylor andS.H. Snyder,Isotopic Microassay of Histamine, Histidine, Histidine Decarboxylase and Histamine Methyltransferase in Brain Tissue, J. Neurochem.19, 1343–1358 (1972).

    PubMed  Google Scholar 

  16. W. Feldberg andJ. Talesnik,Reduction of Tissue Histamine by Compound 48/80, J. Physiol.120, 550–568 (1953).

    PubMed  Google Scholar 

  17. H.V. Ellis, III, A.R. Johnson andN.C. Moran,Selective Release of Histamine from Rat Mast Cells by Several Drugs, J. Pharmacol. Exptl. Therap.175, 627–631 (1970).

    Google Scholar 

  18. M.Z.M. Ibrahim,The Mast Cell in the Mammalian Central Nervous System. Part 1. Morphology, Distribution and Histochemistry, J. Neurol. Sci.21, 431–478 (1974).

    Google Scholar 

  19. P.G. Kruger,Demonstration of Mast Cells in the Albino Rat Brain, Experientia30, 810–811 (1974).

    PubMed  Google Scholar 

  20. C.L. Wong andM.B. Roberts,The Possible Role of Brain Histamine and H 1 and H 2 Receptors in the Development of Morphine Tolerance and Physical Dependence in Mice, Agents and Actions 5 (5) 476–483 (1973).

    Google Scholar 

  21. J.R. Lee andM.R. Fennessy,Effects of Morphine on Brain Histamine, Antinociception and Activity in Mice, Clin. Exper. Pharmacol. Physiol.3, 179–189 (1976).

    Google Scholar 

  22. M. Baudry, M.P. Martres andJ.C. Schwartz,H 1 -and H 2 -Receptors in the Histamine-Induced Accumulation of Cyclic AMP in Guinea-Pig Brain Slices, Nature, Lond.253, 362–364 (1975).

    Google Scholar 

  23. M. Garbarg, G. Barbin, J. Figer andJ.-C. Schwarz,Histaminergic Pathway in Rat Brain Evidenced by Lesions of the Medial Forebrain Bundle, Science186, 833–835 (1974).

    PubMed  Google Scholar 

  24. H.L. Haas,Histamine: Action on Single Hypothalamic Neurones, Brain Res.51, 269–278 (1974).

    Google Scholar 

  25. B.S.R. Sastry andJ.W. Phillis,Evidence for an Ascending Inhibitory Histaminergic Pathway to the Cerebral Cortex, Can. J. Physiol. Pharmacol.54, 782–786 (1976).

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada

    R. W. Henwood Ontario Mental Health Foundation Research Student, in partial fulfilment of requiements for the degree of Ph.D. & I. M. Mazurkiewicz-Kwilecki

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  1. R. W. Henwood Ontario Mental Health Foundation Research Student, in partial fulfilment of requiements for the degree of Ph.D.
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  2. I. M. Mazurkiewicz-Kwilecki
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Additional information

This work was supported by the Ontario Metal Health Foundation Grant No. 379-71D.

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Henwood, R.W., Mazurkiewicz-Kwilecki, I.M. Effect of histidine on morphine-induced changes in brain histamine. Agents and Actions 7, 495–500 (1977). https://doi.org/10.1007/BF02111120

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  • DOI: https://doi.org/10.1007/BF02111120

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