Summary
Concentrations of uric acid (UA) and oxypurines (OP) were enzymatically determined in arterial and venous cord plasma, and in maternal plasma at delivery in normal (n = 45) and hypertensive (n = 22) pregnant women. Concentrations of UA in all samples were significantly higher in hypertensive than in normal pregnancies. Concentrations of OP in hypertensive pregnancies showed a nonsignificant increase as compared with normal pregnancies. There were no significant differences between concentrations of UA or OP in paired samples of arterial or venous cord plasma and maternal plasma.
This finding suggests an easy transfer of UA and OP across the placenta during labor, which is at variance with earlier experimental data obtained in the pregnant rhesus monkey. The hypothesis is put forward, that labor and delivery could influence the facility of placental transfer of UA and OP.
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References
Anderer, M., Schindler, A. E., Liebich, H. M.: Creatinine, urea, and uric acid in amniotic fluid, maternal and umbilical cord blood at delivery. Arch. Gynäkol.220, 65–72 (1975)
Bergmeyer, H. U.: Methoden der enzymatischen Analyse, 2. Aufl., Bd. II, 1874–1887. Weinheim: Verlag Chemie GmbH, 1970
Hayashi, T. T., Gillo, D., Robbins, H., Sabbagha, R. E.: Simultaneous measurement of plasma and erythrocyte oxypurines. I. Normal and toxemic pregnancy. Gynecol. Invest.3, 221–236 (1972)
Krauss, A.: Ursache der Harnsäurebelastung in der Spätschwangerschaft. Arch. Gynäkol.208, 279–282 (1970)
Krauss, A.: Verhalten des Harnsäurespiegels unter der Geburt. Arch. Gynäkol.208, 275–278 (1970)
Kreel, B. K. van, Wallenburg, H. C. S.: Transfer and dynamics of uric acid in the pregnant rhesus monkey. II. A mathematical model. Eur. J. Obstet. Gynecol. Reprod. Biol.8, 219–226 (1978)
Marks, J. F., Kay, J., Baum, J., Curry, L.: Uric acid levels in full-term and low-birth-weight infants. J. Pediatr.73, 609–611 (1968)
Monkus, E. S. J., Nyhan, W. L., Fogel, B. J., Yankow, S.: Concentrations of uric acid in the serum of neonatal infants and their mothers, Am. J. Obstet. Gynecol.108, 91–97 (1970)
Rubaltelli, F. F., Formentin, P. A.: Ammonia nitrogen, urea and uric acid blood levels in the mother and in both umbilical vessels at delivery. Biol. Neonate (Basel)13, 147–154 (1968)
Serr, D. M., Czaczekes, J. W., Zuckerman, H.: Comparative studies on uric-acid levls in amniotic fluid, fetal blood, and maternal blood. Obstet. Gynecol.21, 551–553 (1963)
Stander, H. J., Duncan, E. E., Sisson, W. E.: Chemical studies on toxaemias of pregnancy. Bull. Johns Hopkins Hosp.36, 411–427 (1925)
Wallenburg, H. C. S., van Kreel, B. K.: Transfer and dynamics of uric acid in the pregnant rhesus monkey. I. Transplacental and renal uric acid clearances. Eur. J. Obstet. Gynecol. Reprod. Biol.8, 211–217 (1978)
Wallenburg, H. C. S., van Kreel, B. K.: Comparison of fetal-maternal concentrations of uric acid and oxypurines during labor and post partum. Abstracts 26th Ann. Meeting Soc. Gynecol. Invest., p. 136. San Diego 1979
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Wallenburg, H.C.S., van Kreel, B.K. Maternal and umbilical plasma concentrations of uric acid and oxypurines at delivery in normal and hypertensive pregnancy. Arch. Gynecol. 229, 7–11 (1980). https://doi.org/10.1007/BF02109823
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DOI: https://doi.org/10.1007/BF02109823