Skip to main content
SpringerLink
Log in

Mycobacterial variations as influenced by phage and other genomic factors

  • Published:
Pneumonologie Aims and scope Submit manuscript

Abstract

A photochromogen,M. kansasii, produces cleared areas when plated on heavier inoculations of human, H37Rv, strain. No phage could be demonstrated. From an area spread with H37Rv and theM. kansasii was isolated a chromogenic rough type colony the organism of which produced lesions in guinea pigs. It is suggested that a cross or recombination may have occurred to produce this variant type.

A phage (LEO) isolated from a sarcoid lesion produced three plaque types on H37Rv. One of these, a very turbid plaque type, was isolated in series through fourteen transfers. The three plaque types were produced throughout this series. Phage from the last isolation was plated on ATCC 607, on which only one plaque type was produced. After eight transfers in series on ATCC 607 the phage was plated on H37Rv. On H37Rv it produced the three types of plaques similar to the original. It is suggested that a possible defective prophage may be present in H37Rv that is combining with or influencing the LEO phage thus producing the variant types.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Bertani, G.: A dismune mutant of temperate phage P2. Bact. Proc., 1957 (Abs); p. 38.

  • Cohen, D.: A variant of phage P2 originating inEscherichia coli, strain B. Virology7, 112–126 (1959).

    PubMed  Google Scholar 

  • Delbrück, M.: Wie vermehrt sich ein Bakteriophage? Angew. Chem.66, 391 (1954).

    Google Scholar 

  • Garen, A., Zinder, N. D.: Radiological evidence for partial genetic homology between bacteriophage and host bacteria. Virology1, 347–376 (1955).

    PubMed  Google Scholar 

  • Hershey, A. D., Garen, A., Fraser, D. K., Hudis, J. D.: Growth and inheritance in bacteriophage. Car. Inst. Wash. Yr. Book,53, 210–225 (1954).

    Google Scholar 

  • Luria, S. E.: General Virology. New York: John Wiley & Sons 1953, p. 208.

    Google Scholar 

  • Mankiewicz, E., Van Walbeek, M.: Mycobacteriophages, Their role in tuberculosis and sarcoidosis. Arch. environm. Hlth5, 122–128 (1962).

    Google Scholar 

  • Redmond, W. B.: Is the tubercle bacillus lysogenic? Trans. 15th Conf. Chemotherapy Tuberc. 241–247 (1956).

  • Russell, R. L., Jann, G. J., Froman, S.: Lysogeny in the mycobacteria. I. The establishment of lysogeny. Amer. Rev. resp. Dis.82, 384–393 (1960).

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Tuberculosis Research Laboratory, VA Hospital and Department of Microbiology, Emory University Medical School, Atlanta, Georgia

    W. B. Redmond

Authors
  1. W. B. Redmond
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

A part of the material reported in this paper has been published in: Amer. Rev. resp. Dis.98, 41 (1968).

Rights and permissions

Reprints and permissions

About this article

Cite this article

Redmond, W.B. Mycobacterial variations as influenced by phage and other genomic factors. Pneumologie 142, 191–197 (1970). https://doi.org/10.1007/BF02095215

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02095215

Keywords

Search

Navigation