Abstract
In order to obtain more information on the long-term effects of treatment of Wilm's tumour we investigated 30 subjects treated at the Children's Hospital between 1960 and 1976. All had been nephrectomized and in 4 the length of the remaining kidney was subnormal. In the other subjects kidney length was related to follow up time and age at follow up. Blood pressure was elevated in 5 subjects. Urinary albumin excretion deviated only slightly from normal. Tubular functions were well preserved in all subjects. In this small series we were unable to establish any relation between the abnormalities observed and the treatment given. Our results suggest that, despite wide interindividual variation those who survive Wilm's tumours seldom have long-term renal complications.
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Abbreviations
- GFR:
-
glomerular filtration rate
References
Aperia A, Broberger O, Wikstad I, Wilton P (1977) Renal growth and function in patients nephrectomized in childhood. Acta Paediatr Scand 66:185–192
Brenner BM, Meyer TW, Hostetter TH (1982) Dietary protein intake and the progressive nature of kidney disease: the role of hemodynamically mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation, and intrinsic renal disease. N Engl J Med 307:652–659
Bröchner-Mortensen J, Giese J, Rossing N (1969) Renal inulin clearance versus total plasma clearance of51Cr-Edta. Scand J Clin Lab Invest 23:301–305
Dinkel E, Ertel M, Dittrich M, Peters H, Berres M, Schulte-Wissermann H (1985) Kidney size in childhood Sonographical growth charts for kidney length and volume. Pediatr Radiol 15:38–43
Donaldson SS, Moskowitz PS, Canty EL, Efron B (1978) Radiation-induced inhibition of compensatory renal growth in the weanling mouse kidney. Radiology 128:491–495
Hostetter TH, Olson JL, Rennke HG, Venkatachalam MA, Brenner BM (1981) Hyperfiltration in remnant nephrons: a potentially adverse response to renal ablation. Am J Physiol 241:F85-F93
Hovi L, Koskimies O, Holmberg C, Rajantie J, Rautonen J, Siimes MA (1989) Risk of progressive kidney damage after acute leukaemia. Acta Paediatr Scand 78:608–614
Koskimies O (1982) Arterial hypertension developing 10 years after radiotherapy for Wilm's tumour. Br Med J 285:996–998
Larsson L, Aperia A, Wilton P (1980) Effect of normal development on compensatory renal growth. Kidney Int 18:29–35
Luttenegger TJ, Gooding CA, Fickenscher LG (1975) Compensatory renal hypertrophy after treatment for Wilm's tumor. Am J Roentgen 125:348–351
Moskowitz PS, Donaldson SS, Canty E (1980) Chemotherapy-induced inhibition of compensatory renal growth in the immature mouse. Am J Roentgen 134:491–496
Teppo A-M, Groop L (1985) Urinary excretion of plasma proteins in diabetic subjects. Increased excretion of kappa light chains in diabetic patients with and without proliferative retinopathy. Diabetes 34:589–594
Thomas PRM, Griffith KD, Fineberg BB, Perez CA, Land VJ (1982) Late effects of treatment for Wilm's tumor. Int J Radiat Oncol Biol Phys 9:651–657
Uhari M (1980) Normal blood pressure and hypertension in childhood and adolescence. Thesis, University of Oulu, Oulu, Finland
Wikstad I, Pettersson A, Elinder G, Sökücü S, Aperia A (1986) A comparative study of size and function of the remnant kidney in patients nephrectomized in childhood for Wilm's tumor and hydronephrosis. Acta Paediatr Scand 75:408–414
Zucchelli P, Cagnoli L, Casanova S, Donini U, Pasquali S (1983) Focal glomerulosclerosis in patients with unilateral nephrectomy. Kidney Int 24:649–655
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Mäkipernaa, A., Koskimies, O., Jääskeläinen, J. et al. Renal growth and function 11–28 years after treatment of Wilms' tumour. Eur J Pediatr 150, 444–447 (1991). https://doi.org/10.1007/BF02093729
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DOI: https://doi.org/10.1007/BF02093729