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Ketoconazole susceptibility of yeasts by the FCST method

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Abstract

The flow cytofluorometric susceptibility test (FCST) was extended fromCandida albicans to additional clinically relevant yeasts.Candida tropicalis, C. parapsilosis, C. lusitaniae, C. krusei, C. guilliermondii, Torulopsis glabrata, andRhodotorula rubra were also amenable to the FCST. Of the most frequently encountered yeasts,C. albicans andC. tropicalis exhibited the Emax response, which is believed to be an in vitro indicator of ketoconazole susceptibility with potential clinical relevance.Torulopsis glabrata, for which ketoconazole therapy is less effective, did not exhibit the Emax response; rather it exhibited an MIC effect, but usually at ketoconazole concentrations greater than those therapeutically achievable.

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  1. Department of Microbiology and Immunology, West Virginia University School of Medicine, 26506, Morgantown, WV, USA

    R. Scott Pore

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  1. R. Scott Pore
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Pore, R.S. Ketoconazole susceptibility of yeasts by the FCST method. Current Microbiology 23, 45–50 (1991). https://doi.org/10.1007/BF02092308

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