Summary
Propranolol was administered in a single dose of 80 mg, 120 mg, 160 mg, 240 mg, or 320 mg, to 23 patients with essential mild to moderate hypertension in a randomised, double-blind cross-over study. All treatments produced a significant fall in lying and standing blood pressures compared with placebo, but there was no statistically significant difference in the effects of the different doses. The percentage of patients showing a satisfactory fall in blood pressure was not different in the five treatment groups. The major anti-hypertensive effect of each dose was present by two weeks. The frequency of side-effects were similar on all the doses.
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Gillam, P. M. S., Pritchard, B. N. C.: Discovery of the hypertensive effect of propranolol. Postgrad. Med. J.52 (Suppl. 4), 70 (1976)
Hanssen, L., Olander, R., Åberg, H.: Thrice-daily propranolol treatment for hypertension. Lancet1971/II, 713
Berglund, G., Andersson, O., Larson, O., Wilhelmsson, L.: Anti-hypertensive effect and the effects of Bendrofluometrozide and propranolol. Acta. Med. Scand.199, 499 (1976)
Douglas-Jones, A. P., Cruickshank, J. M.: Once daily dosing with atenolol in patients with mild or moderate hypertension. Br. Med. J.1976/I, 990
Wilson, M., Morgan, G., Morgan, T.: The effect on blood pressure of beta-adrenoceptror blocking drugs administed once daily and their duration of action when therapy is ceased. Br. J. Clin. Pharmacol.3, 857 (1976)
Ross, J., Baber, N. S.: (Personal observation)
Zacharias, F. J., Cowen, K. J., Presst, J., Vickers, J., Wall, B. C.: Propranolol in Hypertension: A study of long-term therapy 1964–1970. Am. Heart. J.83, 755 (1972)
Conway, F. J.: In: Central Action of drugs in Blood Pressure Regulation. Davies, D. S., Reid, J. L. (eds.), p. 277. London: Pitman 1976
Galloway, D. B., Glover, S. C., Hendry, W. G., Logie, H. W., Petrie, J. C., Smith, M. C., Lewis, J. A., Simpson, W. T.: Propranolol in hypertension: A dose response study. Br. Med. J.1976 II, 140
Shand, D.: Pharmacokinetics of propranolol: A review. Postgrad. Med. J.52, (Suppl. 4), 22 (1976)
Wolfson, A. M. J., Knapp, M. S.: Once daily treatment of hypertension. Br. Med. J.1976, 235
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Douglas-Jones, A.P., Baber, N.S. & Lee, A. Once daily propranolol in the treatment of mild to moderate hypertension. Eur J Clin Pharmacol 14, 163–166 (1978). https://doi.org/10.1007/BF02089954
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DOI: https://doi.org/10.1007/BF02089954