Summary
1. Interleukin-10 (IL-10) has a wide range of activities in the immune system such as modulation of interferon-gamma (IFN-γ) and antibody production. The neuropeptide hormone corticotropin (ACTH) has similar activities, suggesting that a bidirectional communication mechanism operates between the immune and the neuroendocrine system involving these two substances.
2. Murine pituitary tumor cells (AtT-20) were found to produce up to 3 ng/ml of IL-10.
3. Pituitary cell corticotropin production was enhanced by IL-10 treatment.
4. IL-10 induced the production of ACTH in mouse splenocytes.
5. Authenticity of pituitary-derived IL-10 was shown by the demonstration of identical neucleic acid sequences of reverse-transcribed, polymerase chain reaction amplified fragments of cDNA obtained from murine splenocytes, a murine pituitary tumor cell line, and freshly isolated murine pituitaries.
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Hughes, T.K., Cadet, P., Rady, P.L. et al. Evidence for the production and action of interleukin-10 in pituitary cells. Cell Mol Neurobiol 14, 59–69 (1994). https://doi.org/10.1007/BF02088589
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DOI: https://doi.org/10.1007/BF02088589