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Cimetidine does not impair pulmonary clearance ofPseudomonas aeruginosa in normal rats

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Abstract

Histamine (H2) -receptor blockers are commonly used in critically ill patients to prevent gastric bleeding and have been implicated in the pathogenesis of gram-negative bacterial (GNB) nosocomial pneumonia. These experiments were undertaken to determine if cimetidine affects pulmonary GNB clearance. Groups of normal Sprague-Dawley rats were given cimetidine (75 mg/kg) or an equal volume of sterile buffer intraperitoneally every 6 hr for 24 hr prior to intratracheal challenge with 1.0 × 108 Pseudomonas aeruginosa. At 6 and 24 hr after challenge, animals were sacrificed and gastric pH, quantitative lung cultures, and total and differential [alveolar macrophages (AM) and polymorphonuclear leukocytes (PMN)] cell counts in bronchoalveolar lavage fluid were performed. Results showed that cimetidine therapy resulting in gastric pH greater than 4.0 has no effect on the pulmonary clearance ofP. aeruginosa.

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Authors and Affiliations

  1. LSU Pulmonary/Critical Care Medicine, LSUMC, 1901 Perdido Street #3205, 70112, New Orleans, Louisiana

    E. Daon BS, W. Summer MD, S. Nelson MD &  C. Mason MD

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  1. E. Daon BS
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  2. W. Summer MD
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  3. S. Nelson MD
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  4. C. Mason MD
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Supported in part by SmithKline Beecham Laboratories, Philadelphia, Pennsylvania.

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Daon, E., Summer, W., Nelson, S. et al. Cimetidine does not impair pulmonary clearance ofPseudomonas aeruginosa in normal rats. Digest Dis Sci 39, 1469–1472 (1994). https://doi.org/10.1007/BF02088050

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  • DOI: https://doi.org/10.1007/BF02088050

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