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Intracellular free calcium as a pathogen in cell damage initiated by the immune system

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Summary

It is proposed that the earliest intracellular event induced by the action of complement is an increase in cytosolic free calcium, which can occur in the absence of lysis. This increase causes morphological and chemical changes in the cell and also results in modified responses to physiological stimuli.

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Authors and Affiliations

  1. Department of Medical Biochemistry, Welsh National School of Medicine, CF4 4XN, Heath Park, Cardiff, UK

    A. K. Campbell & J. P. Luzio

  2. Department of Clinical Biochemistry, University of Cambridge, Addenbrooke's Hospital, Hills Road, CB2 2QR, Cambridge, UK

    A. K. Campbell & J. P. Luzio

Authors
  1. A. K. Campbell
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  2. J. P. Luzio
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Additional information

In this article the term ‘free calcium’ is used to mean ionised calcium, i.e. Ca2+, not bound to ligands.

Acknowledgments. We are grateful to members of the Welsh National School of Medicine, University of Cambridge, School of Clinical Medicine, and the Marine Biological Association Laboratory, Plymouth, for valuable advice and discussions. In particular we thank our colleagues Dr M.B. Hallett, Dr P.J. Richardson and Mr R.A. Daw. We thank the Science and Medical Research Councils, the British Diabetic Association and the Arthritis and Rheumatism Council for supporting our experimental work.

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Campbell, A.K., Luzio, J.P. Intracellular free calcium as a pathogen in cell damage initiated by the immune system. Experientia 37, 1110–1112 (1981). https://doi.org/10.1007/BF02085041

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