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Human cytochromec oxidase during cardiac growth and development

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Summary

Human heart mitochondrial cytochromec oxidase specific content and specific activity was measured in five fetuses 15–21 weeks gestational age and in five patients whose age ranged from 6 days to 22 years. None had evidence of cardiac pathology. An increase in cytochromec oxidase specific content and specific activity was observed in the fetal heart with increasing gestational age (0.13–0.38 nmol hemea/mg protein and 67–295 nmol O2 utilized/min/mg protein) and from the neonatal period (0.35 nmol hemea/mg protein and 140 nmol O2/min/mg protein) to adulthood (1.2 nmol hemea/mg protein and 1104 nmol O2/min/mg protein). A marked increase was observed postnatally between 4 and 19 months.

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  1. Pediatric Cardiology/Department of Pediatrics, UMDNJ-New Jersey Medical School, Newark, New Jersey, USA

    José Marin-Garcia & Leonard S. Baskin

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  1. José Marin-Garcia
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  2. Leonard S. Baskin
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Marin-Garcia, J., Baskin, L.S. Human cytochromec oxidase during cardiac growth and development. Pediatr Cardiol 10, 212–215 (1989). https://doi.org/10.1007/BF02083295

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