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The effect of electrophoretic lignocaine blockade in the region of the carotid sinuses on spontaneous and water diuresis

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Abstract

The effect of electrophoretic lignocaine blockade in the region of the carotid sinuses on changes in the intensity of spontaneous and water diuresis was investigated on anaesthetized dogs. After the blockade a reduction in spontaneous diuresis was observed and a marked and statistically significant restriction of water diuresis was noted as compared with the control experiments. The reduction in diuresis after the blockade was of a brief duration and did not appear to be related to changes in the intensity of the filtration through the kidneys, which was only slightly lower, but to changes in reabsorption. In all probability, the carotid blockade is connected with a dominance of hormonal effects by elimination of the effect of the nervi vagi, osmoreceptors of the carotid arteries and in particular the chemoreceptors of the carotid body.

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References

  1. Beda, E.: Blockade of carotid sinus by means of electrophoresis in treatment of bronchial asthma.Pol. Tyg. Lek. 25, 566 (1970).

    PubMed  Google Scholar 

  2. Bratanova, C., Nachev, N.: Changes in renal function after bilateral cervical vagotomy and compression of carotid arteries in dogs.Eksper. med. i morf. (Sofia)11, 113 (1972).

    Google Scholar 

  3. Chungcharoen, D., de B. Daly, M., Nell, E., Schweitzer, A.: The effect of carotid occlusion upon the intrasinusal pressure with special reference to vascular communications between the carotid and vertebral circulation in the dog, cat and rabbit.J. Physiol. (London) 117, 56 (1952).

    Google Scholar 

  4. Flemming, K., Honig, A., Pötzschke, B., Rauhut, U., Roloff, D., Schulze, Ch.: Renale Natriumausscheidung bei Karotisverschluß vor und nach Ausschalten der Karotischemorezeptoren.Acta Biol. Med. Germ. 30, 85 (1973).

    PubMed  Google Scholar 

  5. Griffin, C. A., Stewart, G. T., Perlmutt, J. H.: Antidiuretic response to occlusion of common carotid arteries in hydrated dogs with transected sinus nerves.Proc. Soc. Exp. Biol. Med. 142, 755 (1973).

    PubMed  Google Scholar 

  6. Handowsky, H., Samaan, A.: Influences des réflexes sino-carotidiens sur l'irrigation sanguine du rein et sur la diurèse.Acta brev. neerl. 9, 243 (1939).

    Google Scholar 

  7. Heymans, C., Neil, E.: Reflexogenic areas of the cardiovascular system. J. & A. Churchill, London 1958.

    Google Scholar 

  8. Hungerland, H.: Änderung der Harnzusammensetzung nach Abklemmung der Arteriae carot. communes.Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 176, 306 (1934).

    Google Scholar 

  9. Janssen, S., Schmidt, J.: Die Carotissinuspolyurie.Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 171, 672 (1933).

    Google Scholar 

  10. Janssen, S.: In: Nierenfunktion und Nervensystem (ed. H. Dutz) Volk und Gesundheit, Berlin 1959.

    Google Scholar 

  11. Kiersz, J.: The effect of unilateral and bilateral carotis sinus blockade by means of lignocaine electrophoresis on changes in blood pressure and respiration in dogs.Roczniki Akademii Medycznej w Poznaniu 9, 43 (1975).

    Google Scholar 

  12. Klisiecki, A., Pickford, M., Rotschild, P., Verney, E. B.: The absorption and excretion of water by the mammal.Proc. Roy. Soc. 112B, 495 (1933).

    Google Scholar 

  13. Leaf, A., Mamby, A. R.: An antidiuretic mechanism not regulated by extracellular fluid tonicity.J. Clin. Invest. 31, 60 (1952).

    PubMed  Google Scholar 

  14. Lemaire, R., Maser, A., Allegrini, J.: Effets sur le volume urinaire de l'hypopression intracarotidienne.C. R. Soc. Biol. 156, 337 (1962).

    Google Scholar 

  15. Lemaire, R., Maser, A., Allegrini, J.: Effets sur la diurèse des hypotensions intracarotidiennes.J. Physiol. (Paris) 54, 369 (1962).

    Google Scholar 

  16. Lemaire, R., Maser, A., Labouche, C., Allegrini, J.: Mécanisme de l'oligurie déclenchée par l'hypopression intracarotidienne.C. R. Soc. Biol. 156, 340 (1962).

    Google Scholar 

  17. O'Connor, W. J.: The excretion of administered sodium chloride by the conscious dog, and the effect of occlusion of the carotid arteries.Quart. J. exp. Physiol. 40, 237 (1955).

    PubMed  Google Scholar 

  18. O'Connor, W. J.: The effect on urinary volume and composition of the ingestion of 0.9 per cent sodium chloride and occlusion of the carotid arteries.Quart. J. exp. Physiol. 43, 367 (1958).

    PubMed  Google Scholar 

  19. Pearce, J. W.: The effect of vagotomy and denervation of the carotid sinus on diuresis following plasma volume expansion.Canad. J. Biochem. 37, 81 (1959).

    PubMed  Google Scholar 

  20. Perlmutt, J. H.: Effect of vagotomy on renal function during water diuresis.Proc. Soc. Exp. Biol. Med. 116, 270 (1964).

    PubMed  Google Scholar 

  21. Potkay, S., Daggett, W. M. Jr., Gilmore, J. P.: Role of the vagus in body water regulation.Amer. J. Physiol. 218, 1333 (1970).

    PubMed  Google Scholar 

  22. Verney, E. B.: Renal excretion of water and salt.Lancet II, 1238, 1295 (1957).

    Google Scholar 

  23. Walser, M., Davidson, D. G., Orloff, J.: The renal clearance of alkali-stable inulin.J. Clin. Invest. 34, 1520 (1955).

    PubMed  Google Scholar 

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  1. Department of Human Physiology, Institute of Physiological Science, Academy of Medicine, Poznań, Poland

    J. Kiersz

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  1. J. Kiersz
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Kiersz, J. The effect of electrophoretic lignocaine blockade in the region of the carotid sinuses on spontaneous and water diuresis. International Urology and Nephrology 9, 53–65 (1977). https://doi.org/10.1007/BF02082666

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  • DOI: https://doi.org/10.1007/BF02082666

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