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Inhibition of glucose utilization in rat diaphragm by peptides of uraemic serum isolated by high-voltage electrophoresis

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Abstract

At least three peptides accumulating in uraemic serum inhibit glucose utilization in the rat diaphragm. The nature of these peptides is unknown. Their amino acid composition was determined. This finding is the first direct evidence differentiating the pathogenesis of abnormal glucose utilization in uraemia from that in diabetes.

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Authors and Affiliations

  1. Research Laboratory of Experimental Therapy, 3rd Medical Clinic, Bratislava-Kramare, Czechoslovakia

    R. Dzúrik, J. Adam & B. Grega

  2. Department of Medical Chemistry, P. J. Šafárik, University Medical School, Košice, Czechoslovakia

    R. Dzúrik, J. Adam & B. Grega

Authors
  1. R. Dzúrik
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  2. J. Adam
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  3. B. Grega
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Dzúrik, R., Adam, J. & Grega, B. Inhibition of glucose utilization in rat diaphragm by peptides of uraemic serum isolated by high-voltage electrophoresis. International Urology and Nephrology 4, 297–301 (1972). https://doi.org/10.1007/BF02081883

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  • DOI: https://doi.org/10.1007/BF02081883

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