Skip to main content
SpringerLink
Log in

Sympathetic activity, plasma renin activity (PRA) and kininogen levels in patients haemodialysed with acetate and bicarbonate

  • Published:
International Urology and Nephrology Aims and scope Submit manuscript

Abstract

Sympathetic, renin and kinin responses to an acetic and bicarbonate fluid in haemodialysed patients were investigated. Increases in dopamine-beta-hydroxylase (DBH) activity, PRA and kininogen levels were found during single dialysis but there was no difference in acetate and bicarbonate haemodialysis. The present results suggest that changes in sympathetic renin and kinin activity were similar in patients treated with either acetate or bicarbonate fluid.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Azava, Y., Ohmori, T., Imai, K., Nava, Y., Matsuoka, M., Hirasawa, Y.: Depressant action of acetate upon the human cardiovascular system.Clin. Nephrol., 8, 477 (1977).

    PubMed  Google Scholar 

  2. Atik, M. O., Bailey, C. J., Turner, S., Peach, M. J., Westervelt, F. B.: Red blood cell catechol-omethyl-transferase, plasma catecholamines and renin in renal failure.Trans. Am. Soc. Artif. Intern. Organs, 12, 195 (1976).

    Google Scholar 

  3. Baldanus, C. A., Ernst, W., Frei, U., Koch, K. M.: Sympathetic and hemodynamic response to volume removal during different forms of renal replacement therapy.Nephron, 31, 324 (1982).

    PubMed  Google Scholar 

  4. Brecht, H. M., Ernst, W., Koch, K. M.: Plasma noradrenaline levels in regular hemodialysis patients.Proc. Eur. Dial. Transplant. Nephrol., 12, 281 (1976).

    Google Scholar 

  5. Briseida, K., Dyruda, E., Rinvika, M.: In vitro estimation of rate of release of kinin in human plasma.Acta Pharmacol. Toxicol., 25, 201 (1967).

    Google Scholar 

  6. Gotch, F.: Hemodialysis. Technical and kinetic considerations. In: Brenner, B., Rector F. C. (eds): The Kidney. W. B. Saunders, Philadelphia 1976, Chapter 14, pp. 1672–1704.

    Google Scholar 

  7. Graefe, U., Follette, W. C., Vizzo, J. E., Goodisan, L. D., Scribner, B. H.: Reduction in dialysis induced morbidity and vascular instability with the use of bicarbonate in dialysate.Proc. Clin. Dial. Transplant Forum, 6, 203 (1976).

    PubMed  Google Scholar 

  8. Janicka, L., Twardowski, Z., Sokoŀowska, G.: Effect of bicarbonate and acetate, dialysate on the course of haemodialysis in chronic renal failure.Pol. Arch. Med. Wewn., 66, 93 (1981).

    PubMed  Google Scholar 

  9. Kevin, J. W., Weiner, M. W.: Acetate transfer across membranes of artificial kidneys in vitro.Kidney Int., 15, 593 (1979).

    PubMed  Google Scholar 

  10. Kirkendal, P. L., Devia, C. J., Bower, J. D., Holbert, R. D.: A comparison of the cardiovascular effects of sodium acetate, sodium bicarbonate and other potential sources of fixed base in hemodialysate solutions.Trans. Am. Soc. Artif. Intern. Organs, 23, 399 (1977).

    PubMed  Google Scholar 

  11. Kokot, F., Supniewski, R.: Radioimmunological and radiocompetence methods applied in clinic.PZWL (Warszawa), 260 (1979).

  12. Ksiażek, A.: Dopamine-beta-hydroxylase activity and catecholamine levels in the plasma of patients with renal failure.Nephron, 24, 170 (1979).

    PubMed  Google Scholar 

  13. Nagatsu, T., Udenfriend, S.: Photometric assay of dopamine-β-hydroxylase activity in human blood.Clin. Chem., 18, 980 (1972).

    PubMed  Google Scholar 

  14. Norello, A., Kelsch, R. C., Easterling, R. E.: Acetate intolerance during hemodialysis.Clin. Nephrol., 5, 29 (1976).

    PubMed  Google Scholar 

  15. Mion, C. E., Hegstrom, R. H., Boen, S. T., Scribner, B. H.: Substitution of sodium acetate for sodium bicarbonate in the bath fluid for hemodialysis.Trans. Am. Soc. Artif. Intern. Organs, 10, 110 (1964).

    PubMed  Google Scholar 

  16. Peuler, J. D., Johnson, G. A.: Simultaneous single isotope radioenzymatic assay of norepinephrine, epinephrine and dopamine of plasma.Life Sci. 21, 625 (1977).

    PubMed  Google Scholar 

  17. Schanberg, S. M., Kirsoner, N.: Serum dopamine-beta-hydroxylase as an indicator of sympathetic activity and primary hypertension.Biochem. Pharmacol. 25, 617 (1976)

    PubMed  Google Scholar 

  18. Spohr, U., Schneider, M. W., Streicher, E., Schack, R., Ritz, E.: Hemofiltration and plasma dopamine-beta-hydroxylase activity.Nephron, 25, 121 (1980).

    PubMed  Google Scholar 

  19. Spohr, U., Ritz, E., Kaden, F.: Plasma dopamine-beta-hydroxylase activity in dialysed patients.Klin. Wochenschr., 55, 1089 (1977).

    PubMed  Google Scholar 

  20. Zucchelli, P., Catizone, K., Espositi, E. D., Fusaroli, M., Ligabue, A., Zuccola, A.: Influence of ultrafiltration on, plasma renin activity and adrenergic system.Nephron, 21, 317 (1978).

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Nephrology, Medical School, Lublin, Poland

    A. Ksiąźek, J. Solski & G. Sokoŀowska

Authors
  1. A. Ksiąźek
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Solski
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. Sokoŀowska
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Supported by the Polish Academy of Sciences.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ksiąźek, A., Solski, J. & Sokoŀowska, G. Sympathetic activity, plasma renin activity (PRA) and kininogen levels in patients haemodialysed with acetate and bicarbonate. International Urology and Nephrology 16, 337–344 (1984). https://doi.org/10.1007/BF02081870

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02081870

Keywords

Search

Navigation