Skip to main content
SpringerLink
Log in

Angiotensin and renal function

  • Published:
International Urology and Nephrology Aims and scope Submit manuscript

Abstract

The effects of angiotensin infused via the renal artery, and subsequently by the venous route, have been studied on the renal function in anaesthetized dogs.

  1. 1.

    Infusion of angiotensin into the renal artery in large doses (0.5 or 1.0 μg per min) produces a fall in the parameters of renal function to a certain level which even more massive doses fail to lower any further.

  2. 2.

    Infusion of angiotensin reduces PAH- and creatinine clearances as well as the excretion of water and sodium.

  3. 3.

    The angiotensin-induced impairment of renal function is attributed to glomerular changes. The results of the present study rule out tubular involvement.

  4. 4.

    The blood pressure changes resulting from administration of angiotensin by the intravenous route are connected with a prompt tachyphylactic effect.

  5. 5.

    In the present study no angiotensin-tachyphylaxis was demonstrable in the renal vessels.

  6. 6.

    The angiotensin-induced retention of sodium and water may reduce the therapeutic value of this substance.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Bartha, J., Szőcs, É.: Angiotensin hatása vesekéreg-szeletek Na-transportjára.Acta physiol. hung. In press.

  2. Barraclough, M. A., Jones, N. F., Marsden, C. D.: Effect of angiotensin on renal function in the rat.Amer. J. Physiol. 212, 1153 (1967).

    PubMed  Google Scholar 

  3. Bock, K. D., Krecke, H. J.: Die Wirkung von synthetischem Hypertensin II auf die PAH- und Inulin-Clearance, die renale Hämodynamik und die Diurese beim Menschen.Klin. Wschr. 36, 69 (1958).

    PubMed  Google Scholar 

  4. Bock, K. D., Gross, F.: Renin and angiotensin tachyphylaxis.Circulat. Res. 9, 1044 (1961).

    PubMed  Google Scholar 

  5. Brown, J. J., Peart, W. S.: The effect of angiotensin on urine flow and electrolyte excretion of hypertensive patients.Clin. Sci. 22, 1 (1962).

    PubMed  Google Scholar 

  6. Cannon, P. J., Ames, R. P., Laragh, J. H.: Indirect action of angiotensin infusion to inhibit renal tubular sodium reabsorption in dogs.Amer. J. Physiol. 211, 1021 (1966).

    PubMed  Google Scholar 

  7. Corcoran, A. C., Page, I. H.: The effects of angiotensin on renal blood flow and glomerular filtration.Amer. J. Physiol. 129, 698 (1940).

    Google Scholar 

  8. Cuypers, Y.: L'action tubulaire rénale de β-angiotensine-II-amide chez le coq.Arch. int. Pharmacodyn. 155, 495 (1965).

    PubMed  Google Scholar 

  9. Finkielman, S., Worcel, M., Massani, Z. M., Nahmod, V. E., Agrest, A., Paladini, A. C.: Angiotensin blood levels in hypovolemic shock during osmotic diuresis.Amer. J. Physiol. 215, 308 (1968).

    PubMed  Google Scholar 

  10. Haas, E., Goldblatt, H.: Pressor effect of renin.Amer. J. Physiol. 207, 1077 (1964).

    PubMed  Google Scholar 

  11. Healy, J. K., Barcena, C., O'Connel, J. M. B., Schreiner, G. E.: Renal and pressor action of angiotensin in the dog.Amer. J. Physiol. 208, 1093 (1965).

    PubMed  Google Scholar 

  12. Itskovitz, H. D., Murphy, J. J., Schoenberg, H. W.: Effects of angiotensin on sodium excretion and renal plasma flow in normotensive and hypertensive patients.Circulation 30, 99 (1964).

    Google Scholar 

  13. Kövér, G., Mályusz, M., Éllő, E., Szőcs, É.: The effect of angiotensin on renal circulation.Acta physiol. Acad. Sci. hung. 28, 53 (1965).

    PubMed  Google Scholar 

  14. Kövér, G., Harza, T., Mályusz, M., Szőcs, É.: Protective effect of sucrose and mannitol against vasoconstriction induced by angiotensin II in the kidney.Acta physiol. Acad. Sci. hung., 33, 19 (1968).

    PubMed  Google Scholar 

  15. Leyssac, P. P.: Thein vivo effect of angiotensin and noradrenalin on the proximal tubule reabsorption of salt in mammalian kidneys.Acta physiol. scand. 64, 167 (1965).

    PubMed  Google Scholar 

  16. Lippman, R. W., Ureen, H. J., Oliver, J.: Mechanism of proteinuria. IV. Effect of renin on haemoglobin excretion.J. exp. Med. 93, 605 (1951).

    PubMed  Google Scholar 

  17. Louis, W. J., Doyle, A. E.: Relationship between the vascular responses to the peptides angiotensin and pitressin.Clin. Sci. 31, 255 (1966).

    PubMed  Google Scholar 

  18. Louis, W. J., Jerums, G.: Tachyphylaxis to alpha- and beta-angiotensin in dogs perfused with Ringer's solution or blood.Circulat. Res. 22, 75 (1968).

    PubMed  Google Scholar 

  19. Lowitz, H. D., Stumpe, K. O., Ochwadt, B.: Micropuncture study of the action of angiotensin II on tubular sodium and water reabsorption in the rat.Nephron 6, 173 (1969).

    PubMed  Google Scholar 

  20. Mandel, M. J., Sapirstein, L. A.: Effect of angiotensin infusion on regional blood flow and regional vascular resistance in the rat.Circulat. Res. 10, 807 (1962).

    PubMed  Google Scholar 

  21. Mc Cubbin, J. W., Page, I. H.: Renal pressor system and neurogenic control of arterial pressure.Circulat. Res. 12, 558 (1963).

    Google Scholar 

  22. Meyer, P., Menard, J., Papanicolu, N., Alexandre, J. M., Devaux, C., Millies, P.: Mechanism of renin release following furosemide diuresis in rabbit.Amer. J. Physiol. 215, 908 (1968).

    PubMed  Google Scholar 

  23. Popper, H., Mandel, E., Mayer, H.: Zur Kreatininbestimmung im Blute.Biochem. Z. 291, 354 (1937).

    Google Scholar 

  24. Schmid, H. E.: Renin, a physiologic regulator of renal hemodynamics.Circulat. Res. 11, 185 (1962).

    PubMed  Google Scholar 

  25. Smith, H. W., Finkelstein, N., Aliminosa, L., Crawford, B., Graber, M.: The renal clearances of substituted hippuric acid derivatives and other aromatic acids in dog and man.J. clin. Invest. 14, 388 (1945).

    Google Scholar 

  26. Takács, L., Kállay, K., Gömöri, P.: A syntheticus angiotensin hatása patkányra a keringő vér redistributiójára.Orv. Hetil. 102, 2272 (1961).

    PubMed  Google Scholar 

  27. Thurau, K., Schnermann, J.: Die Natrium-Konzentration an den Macula densa-Zellen als regulierender Faktor für das Glomerulumfiltrat.Klin. Wschr. 43, 410 (1965).

    PubMed  Google Scholar 

  28. Tost, H., Kövér, G.: Unpublished observation, 1969.

  29. Vander, A. J., Miller, R.: Control of renin secretion in the anesthetized dog.Amer. J. Physiol. 207, 537 (1964).

    PubMed  Google Scholar 

  30. Vander, A. J.: Inhibition of distal tubular sodium reabsorption by angiotensin II.Amer. J. Physiol. 205, 133 (1963).

    PubMed  Google Scholar 

  31. Wakerlin, G. E.: Antibodies to renin as proof of the pathogenesis of sustained renal hypertension.Circulation 17, 653 (1958).

    PubMed  Google Scholar 

  32. Whitney, J., Smith, S., Marmorstein, J., Goodman, H., Sellers, A.: Antidiuretic effect of renin in the dog.J. Physiol. 176, 419 (1954).

    Google Scholar 

  33. Worcel, M., Meyer, P.: Inhibitory effect of angiotensin on renal sodium reabsorption.Pflügers Arch. 317, 124 (1970).

    Google Scholar 

  34. Zimmerman, B. G.: Effect of acute sympathectomy on responses to angiotensin and norepinephrine.Circulat. Res. 11, 780 (1962).

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Physiology, Semmelweis Medical University, Budapest

    Gy. Kövér, T. Bálint & H. Tost

Authors
  1. Gy. Kövér
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. Bálint
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H. Tost
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kövér, G., Bálint, T. & Tost, H. Angiotensin and renal function. International Urology and Nephrology 3, 271–282 (1971). https://doi.org/10.1007/BF02081766

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02081766

Keywords

Search

Navigation