Abstract
Twenty-four-hour urinary specimens from 22 patients with urolithiasis and urinary calcium excretion within the normal range were investigated. The urinary calcium excretion was significantly higher and the urinary osmolar excretion significantly lower in the stone formers than in the normals. Urinary calcium and osmolar excretion as well as urinary magnesium and osmolar excretion both in the patients and in the normals were found to be correlated. In the stone formers urine volume and urinary calcium, magnesium and osmolar excretion, as well as phosphate and osmolar excretion were correlated. These correlations have not been found in the normals. It is thought that in the stone formers the increased excretion of urine is secondary to increased urinary calcium excretion.
Similar content being viewed by others
References
Chambers, R. McK., Dormandy, T. L.: Measurement and interpretation of hypercalciuria on twenty-four-hour urine series.Lancet 2, 1378 (1967).
Fiske, C. H., Subbarov, Y.: The colorimetric determination of phosphorus.J. Biol. Chem. 66, 375 (1925).
Gill, J. R., Bartter, F. C.: On the impairment of renal concentrating ability in prolonged hypercalcemia and hypercalciuria in man.J. clin. Invest. 40, 716 (1961).
Hořejši, J., Slavik, K.: Alkalická a kyselá fosfatasa (modifikace vypracovaná J. Kořínkem). Základy chemického vyšetřování v lékařství. SZdN, Praha 1953.
Isaacson, L. C., Modlin, M., Jackson, W. P. U.: Relative hypercalciuria in nephrolithiasis.Brit. med. J. 3, 558 (1966).
Isaacson, L. C.: Hypercalciuria relative to total solutes in nephrolithiasis.Brit. J. med. 4, 668 (1968).
Isaacson, L. C.: Urinary composition in calcific nephrolithiasis.Invest. Urol. 6, 356 (1969).
Martinez, E., Doolan, P. D.: Determination of creatinine in small quantities of plasma.Clin. Chem. 6, 233 (1960).
Modlin, M.: The interrelation of urinary calcium and sodium in normal adults.Invest. Urol. 4, 180 (1966).
Mori, K.: Direct microcomplexometric analysis of calcium in biological materials.Arch. Biochem. 83, 552 (1959).
Orange, M., Rhein, H. L.: Microestimation of magnesium in body fluids.J. biol. Chem. 189, 379 (1951).
Parfitt, A. M., Higgins, B. A., Nassim, J. R., Collins, J. A., Hilb, A.: Metabolic studies in patients with hypercalciuria.Clin. Sci. 27, 463 (1964).
Phillips, M. J., Cooke, J. N. C.: Relation between urinary calcium and sodium in patients with idiopathic hypercalciuria.Lancet 1, 1354 (1967).
Revúsová, V., Grátzlová, J.: Vylučovanie magnézia v moči a jeho vztah k vápniku v moči u pacientov s urolitiázou. Vnitřní Lek. (in press).
Revúsová, V., Zvara, V.: Dynamika hyperkalkúrie u detí s urolitiázou.Bratisl. lek. Listy 48, 517 (1967).
Revúsová, V., Zvara, V.: Dynamika hyperkalkúrie u detí s urolitiázou. Výsledky dlhodobého sledovania detí.Čs. Pediat. 24, 683 (1969).
Revúsová, V., Zvara, V.: Metabolizmus vápnika pri kalciovej urolitiáze.Rozhl. Chir. 48, 483 (1969).
Schück, O., Cort, J. H.: On the interaction of calcium, sodium, and water transport in the diuresing kidney.Canad. J. Physiol. Pharmacol. 46, 275 (1968).
Sotorník, I., Schück, O., Strříbrná, J.: Influence of diuretics on renal calcium excretion.Experientia 25, 591 (1969).
Tambyah, J. A., Lim, M. K. L.: Effect of furosemide on calcium excretion.Brit. med. J. 1, 751 (1969).
Zvara, V., Revúsová, V.: Hyperkalkúria a jej vzt'ah k tvorbe močových konkrementov u detí.Bratisl. lek. Listy 46, (II), 604 (1966).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Revúsová, V., Zvara, V. & Gratzlová, J. Some laboratory findings in patients with urolithiasis. International Urology and Nephrology 3, 251–258 (1971). https://doi.org/10.1007/BF02081763
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02081763