Skip to main content
SpringerLink
Log in

Do superfused mast cells release histamine by endogenous cation exchange with potassium ions?

  • Histamine Release
  • Published:
Agents and Actions Aims and scope Submit manuscript

Abstract

Isolated rat peritoneal mast cells released histamine on superfusion with isotonic salt solutions or isotonic deionized sucrose. The histamine release followed the kinetics of cation exchange characteristic of the release from similarly superfused isolated mast cell granules and histamine charged carboxylic resin IRC-50. The histamine release was accompanied by an efflux of potassium and ascribed to an endogenous cation exchange K+⇌Hi+ occurring on the passage of outflowing potassium ions over histamine storing granules.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. B. Uvnäs,The mechanism of histamine release from mast cells, In:Handbook of Experimental Pharmacology. Vol. XVIII/2 (Eds. G. V. R. Born, O. Eichler, A. Farah, H. Herken, and A. D. Welsh). Springer-Verlag, Berlin, Heidelberg, New York 1977.

    Google Scholar 

  2. B. Uvnäs, C.-H. Åborg, A. Bergendorff,Storage of histamine in mast cells. Evidence for an ionic binding of histamine to protein carboxyls in the granule heparin-protein complex. Acta Physiol. Scand. suppl.336, 1–26 (1970).

    Google Scholar 

  3. B. Uvnäs, C.-H. Åborg, L. Lyssarides and J. Thyberg,Cation exchanger properties of isolated rat peritoneal mast cells granules. Acta Physiol. Scand.125, 25–31 (1985).

    PubMed  Google Scholar 

  4. B. Uvnäs and C.-H. Åborg,Cation exchange—a common mechanism in the storage and release of biogenic amines stored in granules (vesicles)? II. Comparative studies on sodium-induced release of biogenic amines from the synthetic weak cation exchangers amberlite IRC-50 and Duolite CS-100 and from biogenic (granule-enriched) materials. Acta Physiol. Scand120, 87–97 (1984).

    PubMed  Google Scholar 

  5. B. Uvnäs, C.-H. Åborg and M. Goiny,The kinetics of adrenal catecholamine secretion elicited by splanchnic nerve stimulation or by Ach is consistent with non-exocytotic, multivesicular release on cation exchange basis. Acta Physiol. Scand.123, 249–259 (1985).

    PubMed  Google Scholar 

  6. A. R. Johnson and N. C. Moran,Selective release of histamine from rat mast cells by compound 48/80 and antigen. Am. J. Physiol.216, 453–459 (1969).

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology, Karolinska Institutet, Box 60400, S-10401, Stockholm, Sweden

    B. Uvnäs, C -H. Åborg & L. Lyssarides

Authors
  1. B. Uvnäs
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C -H. Åborg
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. L. Lyssarides
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Uvnäs, B., Åborg, C.H. & Lyssarides, L. Do superfused mast cells release histamine by endogenous cation exchange with potassium ions?. Agents and Actions 20, 146–148 (1987). https://doi.org/10.1007/BF02074653

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02074653

Keywords

Search

Navigation