Abstract
For the purpose of studying the secretion of exogenous toxic metals into hair, relation between their concentrations in hair and those in organs, and the metal shift, Hg or Mn was orally administered to guinea pigs for protracted periods, the distributions of metals in hair and organs were examined by means of neutron activation analysis. It was found that the administration of Hg at high dose resulted in abnormally high Hg levels in hair from the 2nd dosing week and in organs after 25 week dosing, and in a reduced motor activity after 25 week administration. There occurred metal shifts in hair as well. Administration of Mn at high doses, on the other hand, showed no such biological influences, although a dose-dependent increase of Mn in hair was detected with time.
Similar content being viewed by others
References
K. FUHA, Science, 36 (1966) 122.
C. H. LAWRENCE, R. L. COLEMAN, W. L. SOWELL, Bull. Environ. Contamin. Toxic., 3 (1968) 229.
R. L. COLEMAN etc., Bull. Environ. Contamin. Toxic., 3 (1968) 284.
S. MAZALESKI, et al., Am. Ind. Hyg. Assoc. J., 31 (1970) 3.
S. OHMORI, K. HASHIMOTO, Proc. Osaka Pref. Inst. Publ. Health (ed. Ind. Health). 6 (1971) 43.
S. OHMORI, H. TSUJI, Y. KUSAKA, T. TAKEUCHI, T. HAYASHI, J. TAKADA, M. KOYAMA, H. KOZUKA, M. SHINOGI, A. AOKI, K. KATAYAMA, T. TOMIYAMA, J. Radioanal. Chem., 63 (1981) 269.
T. TAKEUCHI, T. HAYASHI, J. TAKADA, M. KOYAMA, Y. KUSAKA, H. TSUJI, S. OHMORI, H. KOZUKA, M. SHINOGI, A. AOKI, K. KATAYAMA, T. TOMIYAMA, J. Radioanal. Chem., 70 (1982) 29.
N. YAMAGATA, Trace Elements, SANGYO, Shuppan, 1977.
F. MORIKAWA, Jap. Dermatol., 82 (1972) 794.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ohmori, S., Hashimoto, K. Neutron activation analysis of trace metals in the hair and organs of small animals treated chronically with Hg and Mn. Journal of Radioanalytical and Nuclear Chemistry, Articles 89, 277–285 (1985). https://doi.org/10.1007/BF02070216
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02070216