Summary
Right ventricular histologic abnormalities have been described in association with arrhythmogenic right ventricular dysplasia, but the cause of the disease is unknown. Identical abnormalities were noted in endomyocardial biopsy specimens from the right and left ventricles of a 20-year-old male patient with the clinical syndrome of arrhythmogenic right ventricular dysplasia. Left ventricular function was normal at rest and during bicycle exercise. Eighteen months previously, he had shown clinical and serologic evidence of mycoplasmal myocarditis. Arrhythmogenic right ventricular dysplasia may represent predominant involvement of the right ventricle in a generalized cardiomyopathic process, possibly as a consequence of healed myocarditis.
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Fontaine G, Guiraudon G, Frank R, Vedel J, Grosgogeat Y, Cabrol C, Facquet J (1977) Stimulation studies and epicardial mapping in ventricular tachycardia: Study of mechanisms and selection for surgery. In: Kulbertus HE (ed) Re-entrant arrhythmias: Mechanisms and treatment. University Park Press, Baltimore, pp 334–350
Marcus FI, Fontaine GH, Guiraudon G, Frank R, Laurenceau JL, Malergue C, Grosgogeat Y (1982) Right ventricular dysplasia: A report of 24 adult cases. Circulation 65: 384–398
Reiter MJ, Smith WM, Gallagher JJ (1983) Clinical spectrum of ventricular tachycardia with left bundle branch morphology. Am J Cardiol 51: 113–121
Pietras RJ, Lam W, Bauernfeind R, Sheikh A, Palileo E, Strasberg B, Swiryn S, Rosen KM (1983) Chronic recurrent right ventricular tachycardia in patients without ischemic heart disease: Clinical, hemodynamic, and angiographic findings. Am Heart J 105: 357–366
Rowland R, McKenna WJ, Sugrue D, Barclay R, Foale RA, Krikler DM (1984) Clinical and electrophysiological features of ventricular tachycardia of left bundle branch block configuration in patients with isolated right ventricular dilatation. Br Heart J 51: 15–24
Manyari DE, Klein GJ, Gulamhusein S, Boughner D, Guiraudon GM, Wyse G, Mitchell LB, Kostuk WJ (1983) Arrhythmogenic right ventricular dysplasia: A generalized cardiomyopathy? Circulation 68: 251–257
Guiraudon GM, Klein GJ, Gulamhusein SS, Painvin GA, Del Campo C, Gonzales JC, Ko PT (1983) Total disconnection of the right ventricular free wall: Surgical treatment of right ventricular tachycardia associated with right ventricular dysplasia. Circulation 67: 463–470
Hammill SC, Holmes DR Jr, Wood DL, Osborn MJ, McLaran C, Sugrue DD, Gersh BJ (1984) Electrophysiologic testing in the upright position: Improved evaluation of patients with rhythm disturbances using a tilt table. J Am Coll Cardiol 4: 65–71
Nippoldt TB, Edwards WD, Holmes DR Jr, Reeder GS, Hartzler GO, Smith HC (1982) Right ventricular endomyocardial biopsy: Clinicopathologic correlates in 100 consecutive patients. Mayo Clin Proc 57: 407–418
Edwards WD, Holmes DR Jr, Reeder GS (1982) Diagnosis of active lymphocytic myocarditis by endomyocardial biopsy: Quantitative criteria for light microscopy. Mayo Clin Proc 57: 419–425
Viola AR, Adaro FVM, Roncoroni AJ (1970) Idiopathic myocardiopathy resulting in failure of contractility of the right ventricle. Am J Med 48: 235–238
Vecht RJ, Carmichael DJS, Gopal R, Philip G (1979) Uhl's anomaly. Br Heart J 41: 676–682
Fitchett DH, Sugrue DD, MacArthur CG, Oakley CM (1984) Right ventricular dilated cardiomyopathy. Br Heart J 51: 25–29
Lewes D, Rainford DJ, Lane WF (1974) Symptomless myocarditis and myalgia in viral and myoplasma pneumonia infections. Br Heart J 36: 924–932
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Sugrue, D.D., Edwards, W.D. & Olney, B.A. Histologic abnormalities of the left ventricle in a patient with arrhythmogenic right ventricular dysplasia. Heart Vessels 1, 179–181 (1985). https://doi.org/10.1007/BF02066415
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DOI: https://doi.org/10.1007/BF02066415