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Tobacco cigarette smoke attenuates duodenal ulcer margin hyperemia in the rat

Comparison of IAP clearance and hydrogen gas clearance techniques for measurements of gastrointestinal blood flow

  • Esophageal, Gastric, And Duodenal Disorders
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Abstract

The hyperemia at the duodenal ulcer margin is important for ulcer healing. We studied the effect of tobacco cigarette smoke on the hyperemia at the margin of mepirizole-induced duodenal ulcer. Duodenal mucosal blood flow values measured by iodo[14C]antipyrine (IAP) autoradiography and hydrogen gas clearance (HGC) were compared. Twenty-four hours after rats were injected with an ulcerogenic dose of mepirizole, they were exposed to tobacco cigarette smoke and duodenal mucosal blood flow was measured by IAP autoradiography. There is a significant correlation between the blood flow measurements by HGC and IAP autoradiography. The hyperemia at the ulcer margin previously demonstrated in our laboratory is absent after exposure of the rats to tobacco cigarette smoke. We speculate that the inhibition of ulcer margin hyperemia could explain the aggravation of duodenal ulcer by tobacco cigarette smoke.

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Authors and Affiliations

  1. the Research and Medical Services, Sepulveda and West Los Angeles Veterans Administration Medical Center, Center for Ulcer Research and Education, UCLA School of Medicine, 91343, Los Angeles, California

    Fumihiro Iwata MD, Oscar U. Scremin MD, PhD &  Felix W. Leung MD

Authors
  1. Fumihiro Iwata MD
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  2. Oscar U. Scremin MD, PhD
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  3. Felix W. Leung MD
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Additional information

This work was supported by Veterans Administration Medical Research Funds, and in part by research grant (1RT 80) provided by the Cigarette and Tobacco Surtax Fund of the State of California through the Tobacco-Related Disease Research Program of the University of California.

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Iwata, F., Scremin, O.U. & Leung, F.W. Tobacco cigarette smoke attenuates duodenal ulcer margin hyperemia in the rat. Digest Dis Sci 40, 1112–1117 (1995). https://doi.org/10.1007/BF02064208

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  • DOI: https://doi.org/10.1007/BF02064208

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