Summary
The effect of a low phosphorus diet on bone resorption is studied in thyroparathyroidectomized rats. Bone resorption is estimated from the marrow cavity area of a cross-section of the tibia. The rate of calcium mobilisation from bone is estimated by serum specific activity of45Ca/40Ca after labelling of the diet. Bone resorption is increased by feeding a low phosphorus diet, suggesting a direct effect of hypophosphatemia stimulating bone resorption, independent of any action of parathyroid hormone.
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Supported in part by a grant from the US Public Health Service (AM 09096).
Recipient of a grant from the Schweizerische Akademie der Wissenschaften, Stiftung für Medizinisch-Biologische Stipendien.
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Binswanger, U., Feist, E. & Rich, C. Bone resorption without parathyroid hormone: Influence of a low phosphorus diet. Z. Gesamte Exp. Med. 156, 61–66 (1971). https://doi.org/10.1007/BF02052977
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DOI: https://doi.org/10.1007/BF02052977