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Occurrence of atypical lymphocytes following intravenous injection of Candida albicans in mice

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Abstract

The occurrence of atypical lymphocytes has been observed in the course of experimental acute infection withCandida albicans in mice. In animals injected intravenously with 2.5 × 106 ofCandida albicans cells, an increased number of monocytes was seen in 24 hours. Monocytes showed toxic vacuolisation in most instances in protoplasm and sometimes in the nuclei. Only a few atypical lymphocytes could be seen at that time. In the following days the number of monocytes diminished and the number of atypical lymphocytes increased. After four days atypical lymphocytes constituted frequently over 20 % of white cells. The autopsy of sacrificed or dead animals with the presence of such elevated percentages of atypical lymphocytes showed enlargement of cervical lymphnodes in all animals. In mice infected with 1.4 × 103 ofCandida albicans cells, no level higher than 12% of atypical lymphocytes was seen. Pictures were returning to normal with only a few atypical lymphocytes present among the animals which survived for two months after infection withCandida albicans.

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Authors and Affiliations

  1. Western Institute for Cancer and Leukemia Research, 90404, Santa Monica, California

    Z. Thaddeus Mankowski M.D.

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  1. Z. Thaddeus Mankowski M.D.
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This work was supported partially byDora Kaplan, Joan Sloan, Cathy Cooper. Memorial Funds and the Roon Foundation.

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Mankowski, Z.T. Occurrence of atypical lymphocytes following intravenous injection of Candida albicans in mice. Mycopathologia et Mycologia Applicata 45, 243–251 (1971). https://doi.org/10.1007/BF02051971

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