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Der Einfluß von Calcitonin auf die experimentelle Osteoporose bei der Ratte

The effect of calcitonin on experimental osteoporosis in the rat

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Zeitschrift für die gesamte experimentelle Medizin einschließlich experimentelle Chirurgie

Summary

16 female Sprague-Dawley rats were ovarectomized. 8 of them were daily injected with 200 mU of calcitonin in 5% gelatin (group B), the other ovarectomized rats (group C) as well as 8 sham-operated control animals (group A) were only injected with the vehicle in 5% gelatin. The experiment lasted 17 weeks. Bone changes following castration and calcitonin-therapy were analyzed by determining weight, density and calcium-content of the femur and spongiosal volume of the 4th caudal vertebra. The ovarectomized rats developed an osteoporosis which was characterized by reduced bone density, and in relation to body-weight by reduced bone-weight and calcium-content. It was impossible to prevent the development of this osteoporosis by longterm treatment with calcitonin, on the other hand calcitonin may have favoured osteolysis via secondary hyperparathyroidism.

Zusammenfassung

16 weibliche Sprague-Dawley-Ratten wurden ovarektomiert, während der 17wöchigen Versuchsdauer erhielten 8 davon täglich 200 mE Calcitonin in 5% Gelatine (Gruppe B), die übrigen ovarektomierten Tiere (Gruppe C) sowie 8 scheinovarektomierte Kontrolltiere (Gruppe A) erhielten das Lösungsmittel in 5% Gelatine. Die Auswirkung der Kastration und der Calcitoninbehandlung auf den Knochen wurde an Hand der folgenden Parameter untersucht: Femurmasse,-dichte und -calciumgehalt sowie Spongiosavolumen des 4. Schwanzwirbelkörpers. Die ovarektomierten Ratten entwickelten eine Osteoporose, die durch verringerte Knochendichte und in bezug auf das Körpergewicht durch verringerte Knochenmasse und -calciumgehalt ausgezeichnet war. Eine Calcitonindauerbehandlung vermochte die Entwicklung dieser Osteoporose nicht zu verhindern, möglicherweise förderte Calcitonin über einen sekundären Hyperparathyreoidismus den Knochenabbau.

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  1. G. Delling

    Present address: Pathologisches Institut der Universität Hamburg, Martinistraße 52, 2000, Hamburg 20

Authors and Affiliations

  1. Abteilung für Innere Medizin, Endokrinologie und Stoffwechsel des Zentrums für Innere Medizin und Kinderheilkunde der Universität Ulm, Deutschland

    S. Bellwinkel, G. Delling & R. Ziegler

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  1. S. Bellwinkel
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  2. G. Delling
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  3. R. Ziegler
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Bellwinkel, S., Delling, G. & Ziegler, R. Der Einfluß von Calcitonin auf die experimentelle Osteoporose bei der Ratte. Z. Gesamte Exp. Med. 156, 259–267 (1971). https://doi.org/10.1007/BF02045827

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  • DOI: https://doi.org/10.1007/BF02045827

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