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Serum enzymes during cardiac allograft rejection

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Zeitschrift für die gesamte experimentelle Medizin einschließlich experimentelle Chirurgie

Summary

In heterotopic allotransplantation of the canine heart without immunosuppression 5 out of 6 enzymes react in some way. There is no change in the values ofα-HBDH. The LDH is elevated 2 days before rejection, but this elevation is not significant. The GPT as well as the lysozyme start to rise 4 days before rejection with a statistically significant elevation one to 2 days before standstill of the transplant. The earliest index of rejection is a rise in serum GOT and CPK which in fact is already significant 4 days before complete rejection. The repeated determination and the careful analysis of these 4 enzymes may therefore contribute to the detection of heart rejection.

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References

  1. Clauvel, M., Schwartz, K., Crépin, Y., Cachéra, J.-P.: Enzyme profiles after heart transplantation. Nature (Lond.)220, 483 (1968).

    Article  CAS  Google Scholar 

  2. Forster, G.: Zur Enzymdiagnostik von Herzinfarkt und Myopathien. Schweiz. med. Wschr.97, 329 (1967).

    PubMed  CAS  Google Scholar 

  3. Largiadèr, F.: Transplantation of the heart. In: Organ Transplantation, 2nd ed. Stuttgart: Thieme 1970.

    Google Scholar 

  4. —, Miller, D. R., Senning, Å., Wegmann, W.: Handhabung und Konservierung von Nierentransplantaten. Helv. chir. Acta34, 10 (1967).

    PubMed  Google Scholar 

  5. —, Senning, Å., Träbert, E., Rosenmund, H.: Erfassung der Abstoßung von Herzhomotransplantaten. Helv. chir. Acta36, 289 (1969).

    PubMed  Google Scholar 

  6. Quentin, D.: Das Serum-Lysozym und sein Verhalten bei Hunden nach Herz-Allotransplantation. Wiederbelebung (im Druck).

  7. Schwartz, K., De Mendonca, M., Crépin, Y., Bui-Mong-Hung, Leandri, J., Cachéra, J. P.: Enzyme release, a test of myocardial damage after dog allogenic heart homotransplantation and heart preservation. Europ. surg. Res.1, 208 (1969).

    Google Scholar 

  8. Shumway, N. E., Lower, R. R., Stofer, R. C.: Transplantation of the heart. In: Advances in Surgery, Vol. II, p. 265. Chicago: Year Book Med. Publ. 1966.

    Google Scholar 

  9. Stinson, E. B., Dong, E., Bieber, C. P., Schroeder, J. S., Shumway, N. E.: Cardiac transplantation in man. I. Early rejection. J. Amer. med. Ass.207, 2233 (1969).

    Article  CAS  Google Scholar 

  10. Uhlschmid, G. K., Largiadèr, F.: Konditionierung von Allotransplantaten mit Ribonukleinsäuren. Helv. chir. Acta37, 270 (1970).

    PubMed  CAS  Google Scholar 

  11. Wegmann, W., Largiadèr, F.: Heterotope, zervikale Herztransplantation beim Hund. Morphologische Befunde. Jahresvers. Verein Schweiz. Path., Baden 1969.

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Authors and Affiliations

  1. Kantonsspital, Chirurgische Universitätsklinik A, Zürich

    O. Bachmann & F. Largiadèr

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  1. O. Bachmann
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  2. F. Largiadèr
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We are indebted to PD Dr. H. Rosenmund and PD Dr. G. Forster (Kantonsspital, Zürich) for their help in enzyme determinations.

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Bachmann, O., Largiadèr, F. Serum enzymes during cardiac allograft rejection. Z. Gesamte Exp. Med. 153, 162–168 (1970). https://doi.org/10.1007/BF02044689

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  • DOI: https://doi.org/10.1007/BF02044689

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