Skip to main content
SpringerLink
Log in

Intra-daily oscillations in dipropylacetic acid plasma levels with two or three daily doses of dipropylacetamide in epileptic patients

  • Original Articles
  • Published:
The Italian Journal of Neurological Sciences Aims and scope Submit manuscript

Abstract

The diurnal fluctuations in dipropylacetic acid (DPA) plasma levels were examined in ten epileptic patients following a chronic treatment with 3 or 2 daily doses of dipropylacetamide (DPM). The highest/lowest DPA level ratios observed throughout 24 hrs were 1.18 and 1.36, respectively, but the difference in the data was not statistically significant (p>0.05). The present results indicate that a reduction of the frequency of the daily administrations of the drug can be made with consequent possible improvement in the patient's compliance. The clinical value of the oscillations in DPA serum levels is also revised in the light of the data reported in the literature.

Sommario

Le fluttuazioni giomaliere dei livelli plasmatici di acido dipropilacetico (DPA) sono state esaminate in 10 pazienti epilettici in trattamento cronico con 3 o 2 dosi giomaliere di dipropilacetamide (DPM). I rapporti valore più alto/valore più basso di livello di DPA osservati nelle 24 ore sono risultati 1.18 e 1.36, rispettivamente, ma la differenza dei dati non è stata significativa (p>0.05). I presenti risultati indicano che può essere effettuata una riduzione della frequenza delle somministrazioni giomaliere del farmaco con un conseguente possibile miglioramento della “compliance” del paziente. Il valore clinico delle oscillazioni dei livelli serici di DPA è inoltre rivisto alla luce dei dati riportati in letteratura.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Chadwick D.W.,Turnbull D.M.,Weightman D.,Rawlins M.D.:Clinical value of valproate levels. 14th Epilepsy International Symposium, London, August 15–18, 1982, (abstracts), pp. 87.

  2. Chard C.R.:A simple method for the determination of Epilim in serum. In: Legg (Ed.), Clinical and Pharmacological Aspects of Sodium Valproate (Epilim) in the Treatment of Epilepsy. MCS Consultants, Tunbridge Wells, 1976, pp. 89–91.

    Google Scholar 

  3. Covanis A.,Jeavons P.M.,Gupta A.K.:Monotherapy with once daily sodium valproate. 12th Epilepsy International Symposium, Copenhagen, September 6–10, 1980, (abstracts), pp. 59.

  4. Odusote K.A. Sherwin Amendola A.L.A.:A simple direct extraction method for gas-liquid determination of valproic acid in plasma.Ther Drug Monit., 3, 103–106, 1981.

    PubMed  Google Scholar 

  5. Lockard L.S., Levy R.H., Congdon W.C., Du Charme L.L. andPatel I.H.:Efficacy testing of valproic acid compared to ethosuximide in monkey model: II. Seizure, EEG, and diurnal variations. Epilepsia, 18, 205–224, 1977.

    PubMed  Google Scholar 

  6. Loiseau P., Brachet A., Henry P.:Concentration of dipropylacetate in plasma. Epilepsia, 16, 609–615, 1975.

    PubMed  Google Scholar 

  7. Meinardi H., Hanke N.F.S., VanBeveren J.:Sodium di-n-propylacetate. Estimation of effective serum levels. Pharm. Wekbl., 109, 45–47, 1974.

    Google Scholar 

  8. Meijer J.W.A. andKalff:Less usual ways of administering antiepileptic drugs. In: H. Schneider, D. Janz, Gardner-Thorpe, H. Meinardi, A.L. Sherwin, (Eds.), Clinical Pharmacology of Anti-Epileptic Drugs. Springer-Verlag, Berlin, Heidelberg, New York, 1975, pp. 222–228.

    Google Scholar 

  9. Perucca E., Gatti G., Frigo G.M., Crema A.:Pharmacokinetics of valproic acid after oral and intravenous administration. Br. J. Clin. Pharmacol., 5, 313–318, 1978.

    Google Scholar 

  10. Perucca E., Gatti G., Frigo G.M., Crema A., Calzetti S., andVisentini D.:Disposition of sodium valproate in epileptic patients. Br. J. Clin. Pharmacol., 5, 495–499, 1978.

    PubMed  Google Scholar 

  11. Pisani F., Amendola D'Agostino A., Fazio A., Oteri G., Primerano G. andDi Perri R.:Increased dipropylacetic acid bioavailability from dipropylacetamide by food. Epilepsia, 23, 115–121, 1982.

    PubMed  Google Scholar 

  12. Pisani F. andDi Perri R.:Some clinical pharmacological aspects of n-dipropylacetamide. It. J. Neurol. Sci., 4, 245–249, 1980.

    Google Scholar 

  13. Pisani F., Fazio A., Oteri G., andDi Perri R.:Dipropylacetic acid plasma levels;diurnal fluctuations during chronic treatment with dipropylacetamide. Ther. Drug Monitor., 3, 297–301, 1981.

    Google Scholar 

  14. Pisani F., Fazio A., Oteri G., andDi Perri R.:A study on the metabolism of dipropylacetamide to dipropylacetic acid in rats. J. Pharm. Pharmacol., 34: 45–46, 1982.

    PubMed  Google Scholar 

  15. Rcihens A., Scoular I.T., Ahmad S., Jordan B.J.:Pharmacokinetics and efficacy of Epilim in patients receiving long-term therapy with other anti-epileptic drugs. In: Legg. (Ed.), Clinical and Pharmacological Aspects of Sodium Valproate (Epilim) in the Treatment of Epilepsy, MCS Consultants, Tunbridge Wells, 1976, pp. 78–88.

    Google Scholar 

  16. Rowan A.J., Binnie C.D., Warfield C.A., Meinardi H., andMeijer J.W.A.:The delayed effect of sodium valproate on photoconvulsive response in man. Epilepsia, 20, 61–88, 1979.

    PubMed  Google Scholar 

  17. Rowan A.J., Meijer J.W.A., Binnie C.D., De Beer-Pawlikowski N., Gutter Th., Goedhart D., van derGeest P., andMeinardi H.:Sodium valproate and sodium valproate-ethosuximide combination therapy: intensive monitoring studies. In: Johannessen S.I., Morselli P.L., Pippenger C.E., Richens A., Schmidt D., Meinardi H., (Eds.), Antiepileptic Therapy: Advances in Drug Monitoring, Raven Press, New York, 1980, pp. 161–168.

    Google Scholar 

  18. Rowan A.J.,Overweg J.,Meijer I.W.A.:Monodose therapy with valproic acid: 24 hours telemetric EEG and serum levels studies. 12th Epilepsy International Symposium, Copenhagen, September 6–10, 1980, (abstracts), pp. 59.

  19. Sackellares J.C., Sato S., Dreifuss F.E., andPenry J.K.:Reduction of Steady-State Valproate Levels by Other Antiepileptic Drugs. Epilepsia, 22, 437–441, 1981.

    PubMed  Google Scholar 

  20. Schmidt D.:Fluctuation of dipropylacetate plasma levels with one and three daily doses. In: Vree T.B. and van der Klein, (Eds), Pharmacokinetics and metabolism of the antiepileptic drug sodium valproate (Depakine, Epilim), Bonn, Scheltema & Holkema, Utrecht, 1977, pp. 22–23.

    Google Scholar 

  21. Schobben F., van derKleijn E., Gabreels F.M.J.:Pharmacokinetics of di-n-propylacetate in epileptic patients. Eur. J. Clin. Pharmacol., 8, 97–105, 1975.

    Article  PubMed  Google Scholar 

  22. Zaccara G. andGalli A.:Effectiveness of Simplified Dosage Schedules on the Management of Ambulant Epileptic Patients. Eur. Neurol., 18, 341–344, 1979.

    PubMed  Google Scholar 

  23. Wulff K., Flachs H., Wurtz-Jorgensen A., Gram L.:Clinical pharmacological aspects of valproate sodium. Epilepsia, 18, 149–157, 1977.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Clinica Neurologica, Università di Messina, Italia

    Pisani F., Spina E., Trunfio C., Fazio A., Oteri G. & Perri R. Di

Authors
  1. Pisani F.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Spina E.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Trunfio C.
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Fazio A.
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Oteri G.
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Perri R. Di
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pisani, F., Spina, E., Trunfio, C. et al. Intra-daily oscillations in dipropylacetic acid plasma levels with two or three daily doses of dipropylacetamide in epileptic patients. Ital J Neuro Sci 4, 173–177 (1983). https://doi.org/10.1007/BF02043901

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02043901

Key-words

Search

Navigation