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“Bolus” methylprednisolone versus ACTH in the treatment of multiple sclerosis

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Abstract

Two groups of 30 multiple sclerosis (MS) patients were randomly treated with corticotrophin (ACTH) and “bolus” 6-methylprednisolone (B/6-MP) to compare the effectiveness of the two treatments. Both ACTH and B/6- MP showed a similar effect, improving acute neurological deficits of MS patients without modifying the long term course of the disease. B/6-MP, showing prompt effectiveness and lack of side effects, may be regarded as a useful alternative to conventional treatment of MS.

Sommario

Due gruppi “random” di 30 pazienti affetti da sclerosi multipla (SM) sono stati trattati con ACTH o “bolo” di 6- metilprednisolone (B/6- MP) allo scopo di confrontare l'efficacia di questi due trattamenti. Sia l'ACTH che il B/6-MP hanno dimostrato un effetto sovrapponibile, migliorando i deficit neurologici acuti dei pazienti senza tuttavia modificare la progressione della malattia. Il trattamento con B/6-MP è risultato caratterizzato da una pronta efficacia con mancanza di effetti collaterali e può pertanto essere considerato un'utile alternativa al trattamento convenzionale della SM.

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Authors and Affiliations

  1. Clinica Neurologica, Università di Genova, Italia

    Abbruzzese G., Gandolfo C. & Loeb C.

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  1. Abbruzzese G.
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  2. Gandolfo C.
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  3. Loeb C.
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Abbruzzese, G., Gandolfo, C. & Loeb, C. “Bolus” methylprednisolone versus ACTH in the treatment of multiple sclerosis. Ital J Neuro Sci 4, 169–172 (1983). https://doi.org/10.1007/BF02043900

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  • DOI: https://doi.org/10.1007/BF02043900

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