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The evolution of a clinically relevant experimental model for the realistic evaluation of long-length (80-cm) arterial prostheses

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Annals of Vascular Surgery

Abstract

A new carotid-femoral experimental model has been developed which has significant clinical relevance to human limb salvage bypass grafting in the areas of graft length, hemodynamics and tissue environment. More significantly, the graft healing pattern observed with this model is similar to what is seen in humans. Therefore, this experimental model provides a challenging and critical site for dynamic healing studies and comparisons of different types of vascular prostheses.

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References

  1. RANDALL RD Jr, WALLEY BD, MEREDITH JH. Comparison of polytetrafluoroethylene (PTFE) and Dacron as long, small-diameter arterial grafts in dogs.Am Surg 1982;48:622–627.

    PubMed  Google Scholar 

  2. National Academy of Sciences Guide for the care and use of laboratory animals. (NIH publication No. 80-23, revised 1978). Washington DC: National Institutes of Health, 1978.

  3. YATES SG, BARROS D'SA AAB, BERGER K, FERNANDEZ LG, WOOD SJ, RITTENHOUSE EA, DAVIS CC, MANSFIELD PB, SAUVAGE LR. The preclotting of porous arterial prostheses.Ann Surg 1978;188:611–622.

    Article  PubMed  CAS  Google Scholar 

  4. JAFFE EA, HOYER LW, NACHMAN RL. Synthesis of antihemophiliac factor antigen by cultured human endothelial cells.J Clin Invest 1973;52:2757–2764.

    Article  PubMed  CAS  Google Scholar 

  5. MATHISEN SR, WU H-D, SAUVAGE LR, USUI Y, WALKER MW. An experimental study of eight current arterial prostheses.J Vasc Surg 1986;4:33–41.

    Article  PubMed  CAS  Google Scholar 

  6. HESS F, JERUSALEM C, BRAUN B. The endothelialization process of a fibrous polyurethane microvascular prosthesis after implantation in the abdominal aorta of the rat.J Cardiovasc Surg 1983;24:516–524.

    CAS  Google Scholar 

  7. ZACHARIAS RK, KIRKMAN TR, CLOWES AW. Mechanisms of healing in synthetic grafts.J Vasc Surg 1987;6:429–436.

    Article  PubMed  CAS  Google Scholar 

  8. SAUVAGE LR, BERGER K, BEILIN LB, SMITH JC, WOOD SJ, MANSFIELD PB. Presence of endothelium in an axillary-femoral graft of knitted Dacron with an external velour surface.Ann Surg 1975;182:749–753.

    Article  PubMed  CAS  Google Scholar 

  9. BERGER K, SAUVAGE LR, RAO AM, WOOD SJ. Healing of arterial prostheses in man: its incompleteness.Ann Surg 1972;175:118–127.

    Article  PubMed  CAS  Google Scholar 

  10. REICHLE FA, STEWART GJ, ESSA N. A transmission and scanning electron microscopic study of luminal surfaces in Dacron and autogenous vein bypasses in man and dog.Surgery 1973;74:945–960.

    PubMed  CAS  Google Scholar 

  11. RAHIF G, URBAN P, BOHLE RM. Morphology of healing in vascular prostheses.Thorac Cardiovasc Surg 1986;34:43–48.

    Article  PubMed  Google Scholar 

  12. WESOLOWSKI SA. The healing of vascular prostheses.Surgery 1965;57:319–324.

    PubMed  CAS  Google Scholar 

  13. SAUVAGE LR, BERGER KE, WOOD SJ, YATES SG II, SMITH JC, MANSFIELD PB. Interspecies healing of porous arterial prostheses.Arch Surg 1974;109:698–705.

    PubMed  CAS  Google Scholar 

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Wu, HD., Arnell, R.E., Sauvage, L.R. et al. The evolution of a clinically relevant experimental model for the realistic evaluation of long-length (80-cm) arterial prostheses. Annals of Vascular Surgery 4, 58–64 (1990). https://doi.org/10.1007/BF02042691

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