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Immunopathology of acute rheumatic fever and rheumatic heart disease. The demonstration of Coxsackie group B viral antigen in the myocardium

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Summary

Immunopathologic studies were performed on heart tissue of patients with acute rheumatic fever with carditis and chronic rheumatic heart disease. Coxsackie group B viral antigen was demonstrated in 3 heart specimens of patients clinically compatible with active rheumatic fever. In two of these the pathologic findings were compatible with acute rheumatic carditis. Immunoglobulin was detected in 2 and complement in one of these heart specimens. All of the chronic rheumatic heart specimens and the controls were negative. These findings suggested that Coxsackie group B virus may be etiologically related to the pathogenesis of acute rheumatic fever.

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Authors and Affiliations

  1. The Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Rama 6 Road, Bangkok, Thailand

    B. Pongpanich M.D. & P. Tanphaichitr

  2. The Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Thailand

    V. Boonpucknavig

  3. Immunopathology Laboratory, Department of Pathobiology, Faculty of Science, Siriraj Hospital, Mahidol University, Bangkok, Thailand

    S. Boonpucknavig

  4. Department of Microbiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand

    C. Wasi

Authors
  1. B. Pongpanich M.D.
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  2. S. Boonpucknavig
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  3. C. Wasi
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  4. P. Tanphaichitr
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  5. V. Boonpucknavig
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Additional information

Supported by Ramathibody Hospital Research Fund, 1980.

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Pongpanich, B., Boonpucknavig, S., Wasi, C. et al. Immunopathology of acute rheumatic fever and rheumatic heart disease. The demonstration of Coxsackie group B viral antigen in the myocardium. Clin Rheumatol 2, 217–222 (1983). https://doi.org/10.1007/BF02041393

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  • DOI: https://doi.org/10.1007/BF02041393

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