Abstract
Acute myocarditis is an inflammatory disease of the myocardium, the most common cause being a viral infection. Acute myocarditis is characterized by oedema and infiltration of pan T lymphocytes and macrophages; variable amounts of myocardial necrosis may occur.
Acute myocarditis is one of the causes of sudden death in athletes.
Sudden death during myocarditis can occur both at rest and during effort and is determined by rapid and often polymorphic ventricular tachycardia, which may degenerate into ventricular fibrillation.
Some experimental studies in animals suggest that physical activity during acute myocarditis increases the replication and aggressiveness of the virus. As a consequence, it is important to diagnose this disease on the basis of a clinical suspicion (fever, etc.), electrocardiographic findings (ST elevation, T wave inversion, etc.), and increase of serum enzymes (CK, CKMB, troponins).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Caforio ALP, Pankuweit S, Arbustini E, Basso C, Gimeno-Blanes J, Felix SB, Fu M, Helio T, Heymans S, Jahn R, Klingel K, Linhart A, Maisch B, McKenna W, Mogensen J, Pinto YM, Ristic A, Schultheiss HP, Seggewiss H, Tavazzi L, Thiene G, Yilmaz A, Charron P, Elliott PM. Current state of knowledge on etiology, diagnosis, management and therapy of myocarditis: a position statement of the European Society of Cardiology working group on myocardial and pericardial diseases. Eur Heart J. 2013;34:2636–48.
Huber SA, Gauntt CJ, Sakkinen P. Enteroviruses and myocarditis: viral pathogenesis through replication, cytokine induction, and immunopathogenicity. Adv Virus Res. 1999;51:35–68.
Klingel K, Hohenadl C, Canu A, Albrecht M, Seemann M, Mall G, Kandolf R. Ongoing enterovirus-induced myocarditis is associated with persistent heart muscle infection: quantitative analysis of virus replication, tissue damage, and inflammation. Proc Natl Acad Sci U S A. 1992;89:314–8.
Malkiel S, Kuan AP, Diamond B. Autoimmunity in heart disease: mechanisms and genetic susceptibility. Mol Med Today. 1996;2:336–42.
Richardson P, McKenna W, Bristow M, Maisch B, Mautner B, O’Connell J, Olsen E, Thiene G, Goodwin J, Gyarfas I, Martin I, Nordet P. Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the definition and classification of cardiomyopathies. Circulation. 1996;93:841–2.
Leone O, Veinot JP, Angelini A, Baandrup UT, Basso C, Berry G, Bruneval P, Burke M, Butany J, Calabrese F, d’Amati G, Edwards WD, Fallon JT, Fishbein MC, Gallagher PJ, Halushka MK, McManus B, Pucci A, Rodriguez ER, Saffitz JE, Sheppard MN, Steenbergen C, Stone JR, Tan C, Thiene G, van der Wal AC, Winters GL. 2011 consensus statement on endomyocardial biopsy from the Association for European Cardiovascular Pathology and the Society for Cardiovascular Pathology. Cardiovasc Pathol. 2012;21:245–74.
Kindermann I, Barth C, Mahfoud F, Ukena C, Lenski M, Yilmaz A, Klingel K, Kandolf R, Sechtem U, Cooper LT, Bohm M. Update on myocarditis. J Am Coll Cardiol. 2012;59:779–92.
Corrado D, Basso C, Rizzoli G, Schiavon M, Thiene G. Does sports activity enhance the risk of sudden death in adolescents and young adults. J Am Coll Cardiol. 2003;42:1959–63.
Magnani JW, Dec GW. Myocarditis: current trends in diagnosis and treatment. Circulation. 2006;113:876–90.
Maron BJ, Doerer JJ, Haas TS, Tierney DM, Mueller FO. Sudden death in young competitive athletes. Analysis of 1866 deaths in the United States, 1980-2006. Circulation. 2009;119:1085–92.
Tilles JG, Lerner AM, Shaka JA, Abelmann WH, Lerner AM, Finland M. Effects of exercise on coxackie A-9 myocarditis in adult mice. Proc Soc Exp Biol Med. 1964;117:777–82.
Gatmaitan BG, Chason JL, Lerner AM. Augmentation of the virulence of murine coxsackie virus B-3 myocardiopathy by exercise. J Exp Med. 1970;131:1121–36.
Morgera T, Di Lenarda A, Dreas L, Pinamonti B, Humar F, Bussani R, Silvestri F, Chersevani D, Camerini F. Electrocardiography of myocarditis revisited: clinical and prognostic significance of electrocardiographic changes. Am Heart J. 1992;124:455–67.
Narula J, Khaw BA, Dec GW, Palacios IF, Southern JF, Fallon JT, Strauss HW, Haber E, Yasuda T. Recognition of acute myocarditis masquerading as acute myocardial infarction. N Engl J Med. 1993;328:100–4.
Sarda L, Colin P, Boccara F, Daou D, Lebtahi R, Faraggi M, Nguyen C, Cohen A, Slama MS, Steg PG, Le Guludec D. Myocarditis in patients with clinical presentation of myocardial infarction and normal coronary angiograms. J Am Coll Cardiol. 2001;37:786–92.
Costantini M, Tritto C, Licci E, Sticchi G, Capone S, Montinaro A, Bruno A, Nuzzaci G, Picano E. Myocarditis with ST-elevation myocardial infarction presentation in young man. A case series of 11 patients. Int J Cardiol. 2005;101:157–8.
Pieroni M, Dello Russo A, Marzo F, Pelargonio G, Casella M, Belloccci F, Crea F. High prevalence of myocarditis mimicking arrhythmogenic right ventricular cardiomyopathy differential diagnosis by electroanatomic mapping-guided endomyocardial biopsy. J Am Coll Cardiol. 2009;53:681–9.
Ukena C, Mahfoud F, Kindermann I, Kandolf R, Kindermann M, Bohm M. Prognostic electrocardiographic parameters in patients with suspected myocarditis. Eur J Heart Fail. 2011;13:398–405.
Zhang T, Miao W, Wang S, Wei M, Su G, Li Z. Acute myocarditis mimicking ST-elevation myocardial infarction: a case report and review of the literature. Exp Therap Med. 2015;10:459–64.
Perazzolo Marra M, De Lazzari M, Zorzi A, Migliore F, Zilio F, Calore C, Vettor G, Tona F, Tarantini G, Cacciavillani L, Corbetti F, Giorgi B, Miotto D, Thene G, Basso C, Iliceto S, Corrado D. Impact of the presence and amount of myocardial fibrosis by cardiac magnetic resonance on arrhythmic outcome and sudden cardiac death in nonischemic dilated cardiomyopathy. Heart Rhythm. 2014;11:856–63.
Wellens HJJ, Conover M. The ECG in emergency decision making. St. Louis: Saunders Elsevier; 1992.
Delise P. Eletrocardiografia 2.0.Il valore aggiunto nell’epoca delle alte tecnologie. Roma: CESI; 2020.
Aquaro GD, Perfetti M, Camastra G, Monti L, Dellegrottaglie S, Moro C, Pepe A, Todiere G, Lanzillo C, Scatteia A, Di Roma M, Pontone G, Perazzolo Marra M, Barison A, Di Bella G. Cardia MR with late gadolinium enhancement in acute myocarditis with preserved systolic function. J Am Coll Cardiol. 2017;70:1977–87.
Aquaro GD, Hbtemicael YG, Camastra G, Monti L, Dellegrottaglie S, Moro C, Lanzillo C, Scatteia A, Di Roma M, Pontone G, Perazzolo Marra M, Barison A, Di Bella G. Prognostic value of repeating caridac magnetic rsonance in patients with acute myocarditis. J Am Coll Cardiol. 2019;74:2439–48.
Das MK, Suradi H, Maskoun W, Michael MA, Shen C, Peng J, Danmaudi G, Mahenthiran J. Fragmented wide QRS on 12-lead ECG. A sign of myocardial scar and poor prognosis. Circ Arrhythm Electrophysiol. 2008;1:258–68.
Take Y, Morita H. Fragmented QRS: what is the meaning? Indian Pacing Electrophysiol J. 2012;12(5):213–25.
Sadeghu R, Dabbagh VR, Tayyebi M, Zakavi SR, Ayati N. Diagnostic value of fragmented QRS complex in myocardial scar detection: systematic review and meta-analysis of the literature. Kardiol Pol. 2016;74(4):331–7.
Fischer K, Margraaf M, Stark AW, Kaneko K, Aghayev A, Guensch DP, Huber AT, Steigner M, Blankstein R, Relchlin T, Windecker S, Kwong RY, Grani C. Association of ECG parameters with late gadolinium enhancement and outcome in patients with clinical suspicion of acute or subacute myocarditis referred for CMR imaging. PLoS One. 2020;15(1):e0227134.
Supreeth RN, Francis J. Fragmented QRS. Its significance. Indian Pacing Electrophysiol J. 2020;20:27–32.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2022 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this chapter
Cite this chapter
Delise, P., Centa, M., Piccoli, G., Scorcu, M. (2022). Acute and Chronic Myocarditis. In: Delise, P., Zeppilli, P. (eds) Sport-related sudden cardiac death. Springer, Cham. https://doi.org/10.1007/978-3-030-80447-3_6
Download citation
DOI: https://doi.org/10.1007/978-3-030-80447-3_6
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-80446-6
Online ISBN: 978-3-030-80447-3
eBook Packages: MedicineMedicine (R0)