Skip to main content

Acute and Chronic Myocarditis

  • Chapter
  • First Online:
Sport-related sudden cardiac death
  • 513 Accesses

Abstract

Acute myocarditis is an inflammatory disease of the myocardium, the most common cause being a viral infection. Acute myocarditis is characterized by oedema and infiltration of pan T lymphocytes and macrophages; variable amounts of myocardial necrosis may occur.

Acute myocarditis is one of the causes of sudden death in athletes.

Sudden death during myocarditis can occur both at rest and during effort and is determined by rapid and often polymorphic ventricular tachycardia, which may degenerate into ventricular fibrillation.

Some experimental studies in animals suggest that physical activity during acute myocarditis increases the replication and aggressiveness of the virus. As a consequence, it is important to diagnose this disease on the basis of a clinical suspicion (fever, etc.), electrocardiographic findings (ST elevation, T wave inversion, etc.), and increase of serum enzymes (CK, CKMB, troponins).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Caforio ALP, Pankuweit S, Arbustini E, Basso C, Gimeno-Blanes J, Felix SB, Fu M, Helio T, Heymans S, Jahn R, Klingel K, Linhart A, Maisch B, McKenna W, Mogensen J, Pinto YM, Ristic A, Schultheiss HP, Seggewiss H, Tavazzi L, Thiene G, Yilmaz A, Charron P, Elliott PM. Current state of knowledge on etiology, diagnosis, management and therapy of myocarditis: a position statement of the European Society of Cardiology working group on myocardial and pericardial diseases. Eur Heart J. 2013;34:2636–48.

    Article  Google Scholar 

  2. Huber SA, Gauntt CJ, Sakkinen P. Enteroviruses and myocarditis: viral pathogenesis through replication, cytokine induction, and immunopathogenicity. Adv Virus Res. 1999;51:35–68.

    Article  Google Scholar 

  3. Klingel K, Hohenadl C, Canu A, Albrecht M, Seemann M, Mall G, Kandolf R. Ongoing enterovirus-induced myocarditis is associated with persistent heart muscle infection: quantitative analysis of virus replication, tissue damage, and inflammation. Proc Natl Acad Sci U S A. 1992;89:314–8.

    Article  CAS  Google Scholar 

  4. Malkiel S, Kuan AP, Diamond B. Autoimmunity in heart disease: mechanisms and genetic susceptibility. Mol Med Today. 1996;2:336–42.

    Article  CAS  Google Scholar 

  5. Richardson P, McKenna W, Bristow M, Maisch B, Mautner B, O’Connell J, Olsen E, Thiene G, Goodwin J, Gyarfas I, Martin I, Nordet P. Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the definition and classification of cardiomyopathies. Circulation. 1996;93:841–2.

    Article  CAS  Google Scholar 

  6. Leone O, Veinot JP, Angelini A, Baandrup UT, Basso C, Berry G, Bruneval P, Burke M, Butany J, Calabrese F, d’Amati G, Edwards WD, Fallon JT, Fishbein MC, Gallagher PJ, Halushka MK, McManus B, Pucci A, Rodriguez ER, Saffitz JE, Sheppard MN, Steenbergen C, Stone JR, Tan C, Thiene G, van der Wal AC, Winters GL. 2011 consensus statement on endomyocardial biopsy from the Association for European Cardiovascular Pathology and the Society for Cardiovascular Pathology. Cardiovasc Pathol. 2012;21:245–74.

    Article  Google Scholar 

  7. Kindermann I, Barth C, Mahfoud F, Ukena C, Lenski M, Yilmaz A, Klingel K, Kandolf R, Sechtem U, Cooper LT, Bohm M. Update on myocarditis. J Am Coll Cardiol. 2012;59:779–92.

    Article  Google Scholar 

  8. Corrado D, Basso C, Rizzoli G, Schiavon M, Thiene G. Does sports activity enhance the risk of sudden death in adolescents and young adults. J Am Coll Cardiol. 2003;42:1959–63.

    Article  Google Scholar 

  9. Magnani JW, Dec GW. Myocarditis: current trends in diagnosis and treatment. Circulation. 2006;113:876–90.

    Article  Google Scholar 

  10. Maron BJ, Doerer JJ, Haas TS, Tierney DM, Mueller FO. Sudden death in young competitive athletes. Analysis of 1866 deaths in the United States, 1980-2006. Circulation. 2009;119:1085–92.

    Article  Google Scholar 

  11. Tilles JG, Lerner AM, Shaka JA, Abelmann WH, Lerner AM, Finland M. Effects of exercise on coxackie A-9 myocarditis in adult mice. Proc Soc Exp Biol Med. 1964;117:777–82.

    Article  CAS  Google Scholar 

  12. Gatmaitan BG, Chason JL, Lerner AM. Augmentation of the virulence of murine coxsackie virus B-3 myocardiopathy by exercise. J Exp Med. 1970;131:1121–36.

    Article  CAS  Google Scholar 

  13. Morgera T, Di Lenarda A, Dreas L, Pinamonti B, Humar F, Bussani R, Silvestri F, Chersevani D, Camerini F. Electrocardiography of myocarditis revisited: clinical and prognostic significance of electrocardiographic changes. Am Heart J. 1992;124:455–67.

    Article  CAS  Google Scholar 

  14. Narula J, Khaw BA, Dec GW, Palacios IF, Southern JF, Fallon JT, Strauss HW, Haber E, Yasuda T. Recognition of acute myocarditis masquerading as acute myocardial infarction. N Engl J Med. 1993;328:100–4.

    Article  CAS  Google Scholar 

  15. Sarda L, Colin P, Boccara F, Daou D, Lebtahi R, Faraggi M, Nguyen C, Cohen A, Slama MS, Steg PG, Le Guludec D. Myocarditis in patients with clinical presentation of myocardial infarction and normal coronary angiograms. J Am Coll Cardiol. 2001;37:786–92.

    Article  CAS  Google Scholar 

  16. Costantini M, Tritto C, Licci E, Sticchi G, Capone S, Montinaro A, Bruno A, Nuzzaci G, Picano E. Myocarditis with ST-elevation myocardial infarction presentation in young man. A case series of 11 patients. Int J Cardiol. 2005;101:157–8.

    Article  Google Scholar 

  17. Pieroni M, Dello Russo A, Marzo F, Pelargonio G, Casella M, Belloccci F, Crea F. High prevalence of myocarditis mimicking arrhythmogenic right ventricular cardiomyopathy differential diagnosis by electroanatomic mapping-guided endomyocardial biopsy. J Am Coll Cardiol. 2009;53:681–9.

    Article  Google Scholar 

  18. Ukena C, Mahfoud F, Kindermann I, Kandolf R, Kindermann M, Bohm M. Prognostic electrocardiographic parameters in patients with suspected myocarditis. Eur J Heart Fail. 2011;13:398–405.

    Article  Google Scholar 

  19. Zhang T, Miao W, Wang S, Wei M, Su G, Li Z. Acute myocarditis mimicking ST-elevation myocardial infarction: a case report and review of the literature. Exp Therap Med. 2015;10:459–64.

    Article  Google Scholar 

  20. Perazzolo Marra M, De Lazzari M, Zorzi A, Migliore F, Zilio F, Calore C, Vettor G, Tona F, Tarantini G, Cacciavillani L, Corbetti F, Giorgi B, Miotto D, Thene G, Basso C, Iliceto S, Corrado D. Impact of the presence and amount of myocardial fibrosis by cardiac magnetic resonance on arrhythmic outcome and sudden cardiac death in nonischemic dilated cardiomyopathy. Heart Rhythm. 2014;11:856–63.

    Article  Google Scholar 

  21. Wellens HJJ, Conover M. The ECG in emergency decision making. St. Louis: Saunders Elsevier; 1992.

    Google Scholar 

  22. Delise P. Eletrocardiografia 2.0.Il valore aggiunto nell’epoca delle alte tecnologie. Roma: CESI; 2020.

    Google Scholar 

  23. Aquaro GD, Perfetti M, Camastra G, Monti L, Dellegrottaglie S, Moro C, Pepe A, Todiere G, Lanzillo C, Scatteia A, Di Roma M, Pontone G, Perazzolo Marra M, Barison A, Di Bella G. Cardia MR with late gadolinium enhancement in acute myocarditis with preserved systolic function. J Am Coll Cardiol. 2017;70:1977–87.

    Article  Google Scholar 

  24. Aquaro GD, Hbtemicael YG, Camastra G, Monti L, Dellegrottaglie S, Moro C, Lanzillo C, Scatteia A, Di Roma M, Pontone G, Perazzolo Marra M, Barison A, Di Bella G. Prognostic value of repeating caridac magnetic rsonance in patients with acute myocarditis. J Am Coll Cardiol. 2019;74:2439–48.

    Article  Google Scholar 

  25. Das MK, Suradi H, Maskoun W, Michael MA, Shen C, Peng J, Danmaudi G, Mahenthiran J. Fragmented wide QRS on 12-lead ECG. A sign of myocardial scar and poor prognosis. Circ Arrhythm Electrophysiol. 2008;1:258–68.

    Article  Google Scholar 

  26. Take Y, Morita H. Fragmented QRS: what is the meaning? Indian Pacing Electrophysiol J. 2012;12(5):213–25.

    Article  Google Scholar 

  27. Sadeghu R, Dabbagh VR, Tayyebi M, Zakavi SR, Ayati N. Diagnostic value of fragmented QRS complex in myocardial scar detection: systematic review and meta-analysis of the literature. Kardiol Pol. 2016;74(4):331–7.

    Article  Google Scholar 

  28. Fischer K, Margraaf M, Stark AW, Kaneko K, Aghayev A, Guensch DP, Huber AT, Steigner M, Blankstein R, Relchlin T, Windecker S, Kwong RY, Grani C. Association of ECG parameters with late gadolinium enhancement and outcome in patients with clinical suspicion of acute or subacute myocarditis referred for CMR imaging. PLoS One. 2020;15(1):e0227134.

    Article  CAS  Google Scholar 

  29. Supreeth RN, Francis J. Fragmented QRS. Its significance. Indian Pacing Electrophysiol J. 2020;20:27–32.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Pietro Delise .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2022 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Delise, P., Centa, M., Piccoli, G., Scorcu, M. (2022). Acute and Chronic Myocarditis. In: Delise, P., Zeppilli, P. (eds) Sport-related sudden cardiac death. Springer, Cham. https://doi.org/10.1007/978-3-030-80447-3_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-80447-3_6

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-80446-6

  • Online ISBN: 978-3-030-80447-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics