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Ion-pair extraction of pentacaine from biological materials

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Abstract

Simple and rapid extraction method for quantitative and selective isolation of the new local anesthetic pentacaine from biological materials is proposed. The technique of ion-pair formation was found to be more effective than usual access using the extraction of the nonionized species. The extraction yield of the unchanged molecule3H-pentacaine after double extraction and single scrubbing was found to be more than 90%. The radiochemical purity was over 90%. The method appears suitable for pharmacokinetic studies in the animal body.

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Author notes

  1. V. Ščasnár

    Present address: Department of Nuclear Medicine and Radiobiology, University of Sherbrooke, Sherbrooke, Quebec, Canada

Authors and Affiliations

  1. Institute of Experimental Pharmacology, Slovak Academy of Sciences, Dubravska cesta, 842 16, Bratislava, (Czechoslovakia)

    V. Ščasnár, L. Beneš, Š. Bezek & T. Trnovec

Authors
  1. V. Ščasnár
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  2. L. Beneš
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  3. Š. Bezek
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  4. T. Trnovec
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Ščasnár, V., Beneš, L., Bezek, Š. et al. Ion-pair extraction of pentacaine from biological materials. Journal of Radioanalytical and Nuclear Chemistry, Articles 82, 287–297 (1984). https://doi.org/10.1007/BF02037051

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  • DOI: https://doi.org/10.1007/BF02037051

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