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Control of obesity inAvy/a mice by 5α-androstan-17-one

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  • Chimica, Biochimica
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Summary

Treating VY/WfL-Avy/a mice with 5α-androstan-17-one, a mammalian glucose-6-phosphate dehydrogenase inhibitor, prevented the mice from becoming obese. The weight difference between treated and controlAvy/a mice was mainly due to a decreased accumulation of triacylglycerol. The compound did not suppress appetite, had no detectable toxicity and did not affect the lipogenesis rates in the liver and carcass. The weight-controlling effect of 5α-androstan-17-one inAvy/a mice was reversible upon withdrawal of treatment.

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References

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Authors and Affiliations

  1. Lilly Research Laboratories, Eli Lilly and Company, 46206, Indianapolis, Indiana, USA

    T. T. Yen, J. A. Allan, D. V. Pearson & J. M. Acton

Authors
  1. T. T. Yen
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  2. J. A. Allan
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  3. D. V. Pearson
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  4. J. M. Acton
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Additional information

The authors wish to thank Mr W.R. Gibson and Drs C.G. Culbertson and P.N. Harris for performing the pathological examinations.

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Yen, T.T., Allan, J.A., Pearson, D.V. et al. Control of obesity inAvy/a mice by 5α-androstan-17-one. Experientia 34, 1542–1543 (1978). https://doi.org/10.1007/BF02034660

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  • DOI: https://doi.org/10.1007/BF02034660

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