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The comparative toxicity for mice of five commonly used nicotine preparations

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Zeitschrift für Präventivmedizin

Summary

Pure nicotine, (−) nicotine, nicotine H+ tartrate, nicotine sullfate and total alkaloids extracted from cigarette smoke (more than 90% nicotine), all of which have been used in much physiological and behavioral research, were compared as to their LD50 in mice. Significant differences in toxicity were noted among several of the preparations, indicating possible differences in potency at supposedly identical dosage levels, in regard to the literature, and also helping to clarity some other discrepancies which exist in experiments where these substances have been used.

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Authors and Affiliations

  1. From the Department of Hygiene and Work Physiology, Division of Behavior Biology, Swiss Federal Institute of Technology, Zurich, Switzerland

    P. Driscoll

Authors
  1. P. Driscoll
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Additional information

Based on a presentation at the scientific meeting of the Swiss Society for Preventive Medicine, Geneva, June 22, 1972.

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Driscoll, P. The comparative toxicity for mice of five commonly used nicotine preparations. Z. Präventivmed 17, 211–213 (1972). https://doi.org/10.1007/BF02034176

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  • DOI: https://doi.org/10.1007/BF02034176

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