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The effect of ATP and certain trace elements on the induction of experimental diabetes

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Summary

The intravenous injection of zinc chloride immediately before and fifteen minutes after alloxan or dithizone prevented the usual hyperglycaemia observed 24 hours after induction of diabetes. This is supported by histological examination which showed that the itslets of those animals which were injected with zinc were intact and their beta cells stained normally.

The intravenous injection of manganese chloride prevented any marked rise of blood glucose, without protecting the islets. Chromium and cobalt chloride lowered the blood-glucose level to a certain extent.

ATP given before alloxan could prevent any marked rise in blood sugar. ATP resulted also in a significant reduction in the fat and significant increase in the glycogen content of the liver in female rats examined on the 10th day after induction of alloxan diabetes.

It is suggested that ATP as well as zinc, manganese, chromium, and cobalt ions seem to be essential for both insulin secretion as well as glucose utilization by various tissues.

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Author notes

  1. Tahani H. Mikhail & R. Awadallah

    Present address: National Research Centre, Dokki, Cairo, Egypt

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    1. Tahani H. Mikhail
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    2. R. Awadallah
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    Mikhail, T.H., Awadallah, R. The effect of ATP and certain trace elements on the induction of experimental diabetes. Z Ernährungswiss 16, 176–183 (1977). https://doi.org/10.1007/BF02024790

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