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The arthus reaction in rats, a possible test for anti-inflammatory and antirheumatic drugs

  • Immunosuppression and Inflammation
  • Research Reports
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Abstract

The Arthus reaction is an immunologically induced inflammatory response characterized by immune complex deposition, complement fixation, polymorphonuclear leukocyte infiltration and tissue damage. Many of these same pathological tissue alterations are found in the lesions of rheumatoid arthritis (RA). The similarities between the reversed passive Arthus reaction (RPAR) and RA led us to investigate the usefulness of the RPAR in the search for new antirheumatic agents. The RPAR was elicited in the skin of rats using chicken ovalbumin and the IgG fraction of rabbit anti-ovalbumin. Paramethasone, hydrocortisone, indomethacin, pirprofen, sulfinpyrazone, thalidomide and theophylline all gave significant inhibition of the RPAR. Ibuprofen, naproxen, cyproheptadine and cromolyn sodium were inactive, while phenylbutazone and ASA exhibited a dose-dependent effect. The data show that the Arthus reaction, which is the result of the complex interaction of many factors, can be affected either generally or selectively at different time intervals by various therapeutic agents. The RPAR in rats may prove useful in detecting new therapeutic agents for the treatment of RA.

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Authors and Affiliations

  1. Research Department, Pharmaceutical Division, Ciba-Geigy Corporation, 10502, Ardsley, New York, USA

    Lawrence R. Pflum & Mary Lee Graeme

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  1. Lawrence R. Pflum
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  2. Mary Lee Graeme
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Pflum, L.R., Graeme, M.L. The arthus reaction in rats, a possible test for anti-inflammatory and antirheumatic drugs. Agents and Actions 9, 184–189 (1979). https://doi.org/10.1007/BF02024732

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  • DOI: https://doi.org/10.1007/BF02024732

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