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Effects of D-Penicillamine on lymphocyte modulation of synovial collagenase production

  • Immunosuppression and Inflammation
  • Research Reports
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Abstract

While D-Penicillamine is effective in the treatment of rheumatoid arthritis, its mechanism of action is unknown. In this study, effects of D-Penicillamine on collagenase production by adherent rheumatoid synovial cells were investigated. D-Penicillamine did not directly affect synovial collagenase production. However, lymphocyte-free-supernatant (LFS) recovered from lymphocytes exposed to D-Penicillamine in vivo and in vitro significantly reduced collagenase production by adherent synovial cells. LFS from lymphocytes of normal subjects and from non-D-Penicillamine treated rheumatoid patients stimulated collagenase production. These investigations indicate that D-Penicillamine indirectly affects collagenase production by cultured synovial cells and suggests beneficial effects on controlling the primary disease process.

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Authors and Affiliations

  1. Battelle Columbus Laboratories, 43201, Columbus, Ohio, USA

    D. P. DeVore, R. J. Gruebel & T. B. Hutson

  2. Richard-H. Turner, M.D., Inc., 43215, Columbus, Ohio, USA

    Richard H. Turner

Authors
  1. D. P. DeVore
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  2. R. J. Gruebel
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  3. T. B. Hutson
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  4. Richard H. Turner
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DeVore, D.P., Gruebel, R.J., Hutson, T.B. et al. Effects of D-Penicillamine on lymphocyte modulation of synovial collagenase production. Agents and Actions 9, 172–176 (1979). https://doi.org/10.1007/BF02024730

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  • DOI: https://doi.org/10.1007/BF02024730

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