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Changes of some lipid and lipid peroxidation characteristics in obese people as a result of a low energy diet

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Summary

In blood samples of 54 obese persons (13 men, 41 women) some lipid components, malondialdehyde (MDA), and the activities of free radical protecting enzymes superoxide-dismutase (SOD) and glutathione-peroxidase (GSHpx), were determined before and after a seven-day slimming diet of 2.1 MJ/day.

Body weight, triglycerides, HDL-cholesterol, and HDL-3-cholesterol all decreased, total cholesterol increased after the seven days hospitalization. After continuing the slimming diet (5.0–6.3 MJ/day) at home, HDL-2-cholesterol increased and total cholesterol returned to the initial value after three months.

MDA decreased in the groups of hyperlipoproteinemia II/a and II/b and also in the group with high cholesterol and triglyceride levels (above 5.7 and 2.7 mmol/l). Correlation coefficients refer to the dominant role of high TG in the intensity of lipid peroxidation.

The activity of SOD fell after the slimming, independent of lipid parameters. GSHpx activity remained unchanged except a drop in the male participants having high cholesterol levels. The behavior of the free radical protecting enzymes needs further examination.

Zusammenfassung

Es wurden vor und nach einer 7tägigen Entfettungskur (2,1 MJ/Tag) von 54 Fettsüchtigen stammende Blutproben auf einige Lipidkomponenten (Malondialdehyd [MDA] und die Aktivität der vor freien Radikalen schützenden Enzyme Superoxid-Dismutase [SOD] und Glutathionperoxidase [GSHpx]) untersucht.

Nach 7tägiger Krankenhausbehandlung wurde eine Erniedrigung des Körpergeichts, der Triglyceride, des HDL-Cholesterin- und des HDL-3-Cholesterins sowie eine Zunahme von Gesamtcholesterin festgestellt. Nach einer zu Hause fortgesetzten drei Monate dauernden Kur (5,0–6,3 MJ) wurde eine Zunahme von HDL-2-Cholesterin und ein Rückgang von Gesamtcholesterin auf den Ausgangswert beobachtet.

Bei an Hyperlipoproteinämie leidenden Vpn. und auch bei denen, die einen erhöhten Cholesterin- und Triglyceridgehalt aufwiesen, wurde eine höhere MDA-Konzentration festgestellt.

Nach der Entfettungskur, unabhängig von den Lipiden, fällt die SOD-Aktivität. Die GSHpx-Aktivität ist unverändert, ausgenommen bei Männern mit hohem Cholesterinniveau.

Weitere Untersuchungen über die vor freien Radikalen schützenden Enzyme sind erforderlich.

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Author notes

  1. E. Dworschák & G. Bíró

    Present address: National Institute of Food Hygiene and Nutrition, Budapest

  2. G. Pados

    Present address: 4th Department of Internal Medicine, Municipal Hospital “Tétényi út”, Budapest

  3. A. Zsinka

    Present address: Central Research Institute of Food Industry, Budapest, Hungary

Authors and Affiliations

  1. National Institute of Food Hygiene and Nutrition, Budapest

    A. Lugasi

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  1. E. Dworschák
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  2. A. Lugasi
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  3. G. Pados
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  4. G. Bíró
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  5. A. Zsinka
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Dworschák, E., Lugasi, A., Pados, G. et al. Changes of some lipid and lipid peroxidation characteristics in obese people as a result of a low energy diet. Z Ernährungswiss 27, 207–215 (1988). https://doi.org/10.1007/BF02019508

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  • DOI: https://doi.org/10.1007/BF02019508

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