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Increased coronary tone in exertional angina: The beneficial effects of calcium antagonists

  • Nifedipine, Cardioprotection, and Ischemic Heart Disease
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Summary

Coronary vasoconstriction may play a relevant role in the pathogenesis of exercise-induced myocardial ischemia, not only in patients with Prinzmetal's angina, but also in patients with chronic stable angina. In these patients the use of calcium antagonists, namely, dihydropyridine derivatives, may be beneficial. Hyperventilation is a simple and sensitive test to discriminate patients with effort angina who will improve their exercise capacity after administration of these drugs.

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Authors and Affiliations

  1. Divisione di Cardiologia Policlinico San Matteo, IRCCS Policlinico San Matteo, 27100, Pavia, Italy

    Giuseppe Specchia MD, Diego Ardissino, Stefano Ghio, Paolo Barberis, Maria Luigia Colombo & Stefano De Servi

  2. Universitá di Pavia, Pavia, Italy

    Giuseppe Specchia MD, Diego Ardissino, Stefano Ghio, Paolo Barberis, Maria Luigia Colombo & Stefano De Servi

Authors
  1. Giuseppe Specchia MD
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  2. Diego Ardissino
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  3. Stefano Ghio
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  4. Paolo Barberis
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  5. Maria Luigia Colombo
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  6. Stefano De Servi
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Specchia, G., Ardissino, D., Ghio, S. et al. Increased coronary tone in exertional angina: The beneficial effects of calcium antagonists. Cardiovasc Drug Ther 4 (Suppl 5), 893–897 (1990). https://doi.org/10.1007/BF02018288

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  • DOI: https://doi.org/10.1007/BF02018288

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