Abstract
The antibody response to cytomegalovirus structural polypeptides in sera from three groups of acutely infected subjects was analyzed. Differences in number and types of polypeptides were noted. Immunoblotting could be used to distinguish sera from patients with acute cytomegalovirus hepatitis from convalescent sera by the detection of antibody to viral proteins of 82, 66, 62, and 55 kilodalton molecular weight at a high serum dilution.
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Landini, M. P., Re, M. C., Mirolo, G., Baldassarri, B., La Placa, M.: Human immune response to cytomegalovirus structural polypeptides studied by immunoblotting. Journal of Medical Virology 1985, 17: 303–311.
Stinski, M. F.: Sequence of protein synthesis in cells infected by human cytomegalovirus. Early and late virus induced polypeptides. Journal of Virology 1978, 26: 686–701.
Landini, M. P., Ripalti, A.: A DNA-nicking activity associated with the nucleocapsid of human cytomegalovirus. Archives of Virology 1982, 73: 351–356.
Griffiths, P. D., Stagno, S., Pass, R. F., Smith, R. J., Alford, C. A.: Congenital cytomegalovirus infection: diagnosis and prognostic significance of the detection of specific immunoglobulin M antibody in cord serum. Pediatrics 1982, 64: 54–59.
Landini, M. P., Coppolecchia, P., Re, M. C., Mirolo, G., La Placa, M.: Serum antibodies to individual cytomegalovirus structural polypeptides in renal transplant recipients during viral infection. Microbiology and Immunology 1986, 30: 683–695.
Rasmussen, L., Kelsall, D., Nelson, R., Carney, W., Hirsch, M., Winston, D., Preiksaitis, J., Merigan, T. C.: Virus specific IgG and IgM antibodies in normal and immunocompromised subjects infected with cytomegalovirus. Journal of Infectious Diseases 1982, 145: 191–199.
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Mirolo, G., Baldassarri, B., Ripalti, A. et al. Antibody response to individual cytomegalovirus structural proteins in different groups of subjects. Eur. J, Clin. Microbiol. 6, 207–210 (1987). https://doi.org/10.1007/BF02018217
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DOI: https://doi.org/10.1007/BF02018217