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Successful treatment of recurrent cerebral empyema and brain abscesses with Imipenem

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Abstract

Imipenem was successfully used to treat a case of subdural empyema complicated by multiple cerebral abscesses, in which surgery and therapy with other antibiotics had previously failed. Imipenem concentrations in serum, cerebrospinal fluid and the cerebral abscess were much higher than the MICs for the infecting organisms, qualifying this antibiotic as an effective option in therapy of suppurative intracranial infections.

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References

  1. Birnbaun, J., Kahan, F. M., Kropp, H., McDonald, J. S.: Carbapenems, a new class of beta-lactam antibiotics. American Journal of Medicine 1985, 78, Supplement 6A: 3–21.

    Article  Google Scholar 

  2. Geddes, A. M., Stille, W.: Imipenem: the first thienamycin antibiotic. Reviews of Infectious Diseases 1985, 7, Supplement 3: S353-S366.

    PubMed  Google Scholar 

  3. Wang, C., Calandra, G. B., Aziz, M. A., Brown, K. R.: Efficacy and safety of imipenem/cilastatin: a review of worldwide clinical experience. Reviews of Infectious Diseases 1985, 7, Supplement 3: S528-S536.

    PubMed  Google Scholar 

  4. Modai, J., Vittecoq, D., Decazes, J. M., Meulemans, A.: Penetration of imipenem and cilastatin into cerebrospinal fluid of patients with bacterial meningitis. Journal of Antimicrobial Chemotherapy 1985, 16: 751–755.

    PubMed  CAS  Google Scholar 

  5. Bannister, G., Williams, B., Smith, S.: Treatment of subdural empyema. Journal of Neurosurgery 1981, 55: 82–88.

    Article  PubMed  CAS  Google Scholar 

  6. Kropp, H., Gerckens, L., Sundelof, J. G., Kahan, F. M.: Antibacterial activity of imipenem: the first thienamycin antibiotic. Reviews of Infectious Diseases 1985, 7, Supplement 3: S389-S410.

    PubMed  CAS  Google Scholar 

  7. Calandra, G. B., Wang, C., Aziz, M., Brown, K. R.: The safety profile of imipenem/cilastatin: worldwide clinical experience based on 3470 patients. Journal of Antimicrobial Chemotherapy 1986, 18, Supplement E: 193–202.

    PubMed  Google Scholar 

  8. Sik Kim, K.: Comparison of cefotaxime, imipenem-cilastatin, ampicillin-gentamicin and ampicillin-chloramphenicol in the treatment of experimentalEscherichia coli bacteremia and meningitis. Antimicrobial Agents and Chemotherapy 1985, 28: 433–436.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Infectious Disease Unit, Hospital Nuestra Señora de Covadonga, Universidad de Oviedo, Celestino Villamil s/n, 33006, Oviedo, Spain

    J. A. Carton, F. Perez, J. A. Maradona & F. J. Mendez

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  1. J. A. Carton
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  2. F. Perez
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  3. J. A. Maradona
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  4. F. J. Mendez
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Carton, J.A., Perez, F., Maradona, J.A. et al. Successful treatment of recurrent cerebral empyema and brain abscesses with Imipenem. Eur. J, Clin. Microbiol. 6, 578–580 (1987). https://doi.org/10.1007/BF02014252

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  • DOI: https://doi.org/10.1007/BF02014252

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