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Time course of the pharmacological response to beta-lactam antibiotics in vitro and in vivo

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Abstract

Experimental examples of different beta-lactam-organism combinations in vitro and in vivo are presented to demonstrate that a rationale for dosage regimens of antibiotics should not be based solely on pharmacokinetic parameters. The time course of the pharmacological response (onset and speed of bacterial killing) and the presence or absence of a postantibiotic effect must also be considered. Such pertinent information can be derived from in vitro studies such as time-kill curves and regrowth curves of bacteria obtained at and after short exposure of the target organisms to various concentrations of the drug.

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Authors and Affiliations

  1. Department of Medicine, University of Bern, Insełspital, 3010, Bern, Switzerland

    A. U. Gerber, C. Feller & H. P. Brugger

Authors
  1. A. U. Gerber
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  2. C. Feller
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  3. H. P. Brugger
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Gerber, A.U., Feller, C. & Brugger, H.P. Time course of the pharmacological response to beta-lactam antibiotics in vitro and in vivo. Eur. J, Clin. Microbiol. 3, 592–597 (1984). https://doi.org/10.1007/BF02013630

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  • DOI: https://doi.org/10.1007/BF02013630

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