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Comparative activity of LY146032 against anaerobic cocci

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Abstract

Fifty strains of anaerobic gram-positive cocci were tested in vitro against benzylpenicillin, teicoplanin, vancomycin and LY146032. The organisms displayed a wide range of susceptibility to penicillin and the minimum inhibitory concentration for 11 of the strains was ≥1 mg penicillin/L. The activity of teicoplanin exceeded that of vancomycin by a factor of two. The activity of LY146032 varied in different culture media and was dramatically potentiated by the addition of a physiological concentration of calcium. Peptococci were, in general, more susceptible than peptostreptococci to penicillin and to LY146032 in the absence of added calcium.

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References

  1. Eliopoulos, G. M., Willey, S., Reiszner, E., Spitzer, P. G., Caputo, G., Moellering, R. C.: In vitro and in vivo activity of LY146032, a new cyclic lipopeptide antibiotic. Antimicrobial Agents and Chemotherapy 1986, 30: 532–535.

    PubMed  Google Scholar 

  2. Ehlert, F., Neu, H. C.: In vitro activity of LY146032 (daptomycin), a new peptolide. European Journal of Clinical Microbiology 1987, 6: 84–90.

    PubMed  Google Scholar 

  3. Andrew, J. H., Wale, U.C.J., Wale, L. J., Greenwood, D.: The effect of cultural conditions on the activity of LY146032 against staphylococci and streptococci. Journal of Antimicrobial Chemotherapy 1987, 20: 213–221.

    PubMed  Google Scholar 

  4. Glupczynski, Y., Labbe, M., Orokaert, F., Yourassowsky, E.: In vitro activity of teicoplanin and vancomycin against anaerobes. European Journal of Clinical Microbiology 1984, 3: 50–51.

    PubMed  Google Scholar 

  5. Aldridge, K. E., Sanders, C. V., Lewis, A. C., Marier, R. L.: Susceptibility of anaerobic bacteria to beta-lactam antibiotics and beta-lactamase production. Journal of Medical Microbiology 1983, 16: 75–82.

    PubMed  Google Scholar 

  6. Wren, M. W. D., Eldon, C. P., Dakin, G. H.: Novobiocin and the differentiation of peptococci and peptostreptococci. Journal of Clinical Pathology 1977, 30: 620–622.

    PubMed  Google Scholar 

  7. Applebaum, P. C., Chatterton, S. A.: Susceptibility of anaerobic bacteria to ten antimicrobial agents. Antimicrobial Agents and Chemotherapy 1978, 14: 371–376.

    PubMed  Google Scholar 

  8. Sutter, V. L.: Frequency of occurrence and antimicrobial susceptibility of bacterial isolates from the intestinal and female genital tracts. Reviews of Infectious Diseases 1983, 5, Supplement 1: 84–89.

    Google Scholar 

  9. Nord, C. E., Olsson-Liljequist, B.: Anaerobic bacteria and beta-lactam antibiotics. Scandinavian Journal of Infectious Diseases 1984, Supplement 42: 72–82.

    Google Scholar 

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Authors and Affiliations

  1. Department of Microbiology and Public Health Service Laboratory, University Hospital, Queen's Medical Center, NG7 2UH, Nottingham, UK

    D. Greenwood & J. Palfreyman

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  1. D. Greenwood
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  2. J. Palfreyman
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Greenwood, D., Palfreyman, J. Comparative activity of LY146032 against anaerobic cocci. Eur. J, Clin. Microbiol. 6, 682–684 (1987). https://doi.org/10.1007/BF02013071

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  • DOI: https://doi.org/10.1007/BF02013071

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