Summary
The influence of phenobarbital and TCDD pretreatment on the formation and biliary excretion of TCDD-metabolites following single doses of3H-TCDD was investigated. Without pretreatment, 24.5% of the absorbed3H-TCDD dose was excreted in the bile within 110 h. Phenobarbital did not influence this rate, whereas a single dose of 10 μg of unlabeled TCDD/kg b.wt nine days earlier resulted in a doubling of the amount of radioactive material eliminated in the bile (47.4%).
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Poiger, H., Schlatter, C. Influence of phenobarbital and TCDD on the hepatic metabolism of TCDD in the dog. Experientia 41, 376–378 (1985). https://doi.org/10.1007/BF02004514
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DOI: https://doi.org/10.1007/BF02004514